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FGF20 — FXR1

Text-mined interactions from Literome

Inagaki et al., Cell Metab 2005 : FGF15 expression is stimulated in the small intestine by the nuclear bile acid receptor FXR and represses Cyp7a1 in liver through a mechanism that involves FGF receptor 4 (FGFR4) and the orphan nuclear receptor SHP
Gutierrez et al., Arterioscler Thromb Vasc Biol 2006 (Atherosclerosis...) : Hepatic PON1 and CYP7A1 mRNA expression is repressed by bile acids via FXR mediated induction of FGF15
Shin et al., J Biol Chem 2009 : The bile acid receptor FXR ( farnesoid X receptor ) activates expression of fibroblast growth factor ( FGF ) 15 in the intestine, which acts through hepatic FGFR4 to suppress cholesterol-7alpha hydroxylase ( CYP7A1 ) and limit bile acid production
Mencarelli et al., J Cell Mol Med 2010 (Atherosclerosis) : In the intestine FXR induces the release of fibroblast growth factor 15 ( FGF15 ) ( or FGF19 in human ), which activates hepatic FGF receptor 4 (FGFR4) signalling to inhibit bile acid synthesis
Zhang et al., PloS one 2011 : Both resin fed and FXR-null mouse models indicate that BAs regulate their own biosynthesis through the FXR regulated ileal fibroblast growth factor 15
Kong et al., Hepatology 2012 : FXR mediated induction of hepatic small heterodimer partner ( SHP/Shp, Nr0b2 ) and intestinal fibroblast growth factor 15 ( Fgf15 ; FGF19 in humans ) has been shown to be responsible for this suppression