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RAC1 — VCAM1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Chen et al., J Pharmacol Exp Ther 2003
:
In contrast, Ad.N17Rac1 inhibited TNF-alpha induced NF-kappaB-driven HIV ( kappaB ) ( 4 ) -CAT and p288VCAM-Luc promoter activity, suggesting that
N17Rac1 inhibits TNF-alpha induced
VCAM-1 , E-selectin, and ICAM-1 through suppressing NF-kappaB mediated transactivation
Cook-Mills et al., Biochem J 2004
(Calcium Signaling) :
Calcium mobilization and
Rac1 activation are
required for
VCAM-1 ( vascular cell adhesion molecule-1 ) stimulation of NADPH oxidase activity ... Furthermore, VCAM-1 specifically activated the Rho-family GTPase Rac1, and
VCAM-1 activation of NADPH oxidase was
blocked by a dominant negative
Rac1
Marchese et al., Biochemistry 2012
:
In contrast, S730 and S737, but not S728 or Y729, were necessary for
VCAM-1 activation of
Rac1 ... Together, these data indicate that S728 and Y729, and S730 and S737, are distinct functional sites that coordinate
VCAM-1 activation of calcium fluxes and
Rac1 during leukocyte transendothelial migration
Wu et al., Biochem Pharmacol 2013
(Inflammation) :
The
Rac-1 activation and ROS liberation
mediated TNF stimulated NF-?B activation and the subsequent
VCAM-1 and ICAM-1 expression