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LCK — TYR

Text-mined interactions from Literome

Hartley et al., J Biol Chem 1999 : Lck has been shown previously to be activated by either phosphorylation of Tyr394 or dephosphorylation of Tyr505
Salvador et al., Nat Immunol 2005 (MAP Kinase Signaling System) : Thus, phosphorylation of Tyr323 dependent on the tyrosine kinase Lck and mediated by Zap70 serves as an important mechanism for TCR activation of p38 in T cells
Bergman et al., EMBO J 1992 : Phosphorylation of Tyr-505 suppressed the catalytic activity of p56lck
Pallandre et al., J Immunol 2007 (Disease Models, Animal...) : We demonstrated that CD28 activation in CD4 ( + ) CD25 ( - ) T lymphocytes leads to STAT3 Tyr ( 705 ) phosphorylation in an Lck dependent manner
Hardwick et al., Proc Natl Acad Sci U S A 1995 (Leukemia, T-Cell) : Using mutant forms of Lck, we found that Tyr-394 is required for H2O2 induced activation of Lck , suggesting that phosphorylation of this site may activate Lck
Burnett et al., Blood 1994 (Leukemia-Lymphoma, Adult T-Cell...) : Because phosphorylation of Tyr-505 in vivo regulates the tyrosine kinase activity of p56lck we amplified a region from LCK exon 12 that contains the codon for Tyr-505 and showed no mutation of this codon in HSB-2 DNA and, therefore, p56lck in HSB-2 is not activated by mutation of Tyr-505
Hardwick et al., J Biol Chem 1997 : These results indicate that activation of Lck by phosphorylation of Tyr-394 is dominant over any inhibition induced by phosphorylation of Tyr-505