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ABL1 — TYR
Text-mined interactions from Literome
Dorey et al., Oncogene 2001
:
Phosphorylation of
Tyr412 can occur autocatalytically by a trans-mechanism and
cause activation of otherwise inactive
c-Abl , suggesting a positive feedback loop on c-Abl activity ...
Tyr412 is therefore
necessary both for activity and for regulation of
c-Abl , by stabilizing the inactive or the active conformation of the enzyme in a phosphorylation dependent manner
Yu et al., J Biol Chem 2004
:
c-Abl mediated phosphorylation of topo I
Tyr268 in vitro and in cells conferred activation of the topo I isomerase function
Holcomb et al., J Biol Chem 2006
:
Our findings indicate that regulated protein degradation by the proteasome specifically controls cell death through regulation of
Abl mediated Crk
Tyr221 phosphorylation and assembly of the CAS-Crk signaling scaffold