Hashimoto et al., Br J Pharmacol 2001
:
To clarify these issues, we examined the effect of NAC on TNF-alpha induced activation of p38 MAP kinase, MAP kinase kinase (MKK) 3 and MKK6 which are upstream regulators of p38 MAP kinase, and p38 MAP kinase mediated IL-8 production
Saeki et al., Biochem J 2002
(MAP Kinase Signaling System) :
In addition, dithiothreitol also suppressed both apoptosis and JNK/p38 activation by EGCG, and EGCG induced activation of MAP kinase kinase (MKK) 3/6 , MKK4 and apoptosis regulating kinase 1 (ASK1) was suppressed by NAC