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CD8A — IFNG

Text-mined interactions from Literome

El-Sheikh et al., J Autoimmun 1999 (Diabetes Mellitus, Type 1) : Both CD4 ( + ) and CD8 ( + ) T cells are required for IFN-gamma gene expression in pancreatic islets and autoimmune diabetes development in biobreeding rats ... Depletion of either CD4 ( + ) or CD8 ( + ) T cells completely prevented IFN-gamma mRNA upregulation in islets of DP-BB rats above the low level expressed in islets of diabetes-resistant ( DR ) BB rats
Cousens et al., J Exp Med 1999 (Lymphocytic Choriomeningitis) : Under normal conditions of infections, the CD8 T cell IFN-gamma response was dependent on endogenous IFN-alpha/beta effects, but was IL-12 independent
Dobashi et al., Hepatology 1999 : In addition, liver MNC acquired a potent antitumor cytotoxicity by the SEB injection, and both NK cells and NK1 ( + ) T cells but not cluster of differentiation (CD)8 ( + ) T cells were responsible for the cytotoxicity as demonstrated by either in vivo or in vitro cell depletion experiments, and the NK-type cells were partly responsible for the increased serum IFN-gamma
Berger et al., Virology 2000 (Disease Models, Animal...) : ( 3 ) Production of interferon-gamma , obligatory for resolution of persistent infection, is dependent on the interaction of virus-specific CD4 ( + ) and CD8 ( + ) T cells
Yun et al., Infect Immun 2000 (Coccidiosis) : Selective depletion of CD4 ( + ), but not CD8 ( + ), cecal tonsil lymphocytes in SC chickens resulted in a reduced IFN-gamma mRNA expression, indicating that CD4 ( + ) cells are the primary source of this cytokine
Tvinnereim et al., Infect Immun 2000 : IFN-gamma knockout ( KO ) mice were used to address the requirement for IFN-gamma in CD8 ( + ) T-cell priming against ( i ) a model exogenous antigen and ( ii ) secreted and nonsecreted L. monocytogenes antigens
Wu et al., Eur J Immunol 2000 : The presence of IFN-alpha or IFN-gamma in cultures enhanced IL-12Rbeta2 expression of CD4 ( + ) and CD8 ( + ) T cells
Peng et al., J Immunol 2000 : Soluble CD8 selectively inhibited CD8 T cell proliferation and IFN-gamma production and could also attenuate peptide-specific CD8 T cell responses in vivo
Grohmann et al., J Immunol 2001 (Diabetes Mellitus, Type 1) : IFN-gamma enhances the inhibitory activity of CD8 ( + ) DC on Ag presentation by the other subset, blocking the ability of IL-12 treated CD8 ( - ) DC to overcome suppression
Kumar et al., J Immunol Methods 2001 : In two monkeys studied in detail, the IFN-gamma response was focussed on a single 20-mer peptide, QGDGANAGQPQAQGDGANAG, and was dependent on CD4 ( + ), but not CD8 ( + ), T cells
Noël et al., Int Immunol 2001 : The production of both IFN-gamma and IL-2 following SEB stimulation was greatly impaired in co-cultures containing CD4 ( + ) T cells, but not CD8 ( + ) T cells, isolated from unresponsive animals
Giovannetti et al., Clin Exp Immunol 2001 (HIV Infections) : The number of anti-HIV Gag and Pol cytotoxic T lymphocytes precursors ( CTLp ) decreased during HAART and highly correlated with the CD8 IFN-gamma response
Grohmann et al., J Immunol 2001 : By virtue of their respective actions on CD8 ( - ) and CD8 ( + ) DC, IL-12 and IFN-gamma have functionally opposing effects on peptide presentation by the CD8 ( - ) DC subset, and IFN-gamma activated CD8 ( + ) DC mediate tolerogenic effects that prevail over the adjuvant activity of IL-12 on CD8 ( - ) DC
Kafrouni et al., J Immunol 2001 : Delayed clearance of AdCMV-lacZ from the livers of FasL-defective B6.gld mice, but not perforin-deficient B6.pfp ( -/- ) mice, was noted despite no significant differences in initial hepatic CD8 ( + ) T cell IFN-gamma or TNF responses or in activation of intrahepatic cytotoxic lymphocytes cells capable of killing AdCMV-lacZ infected fibroblast targets
Wang et al., Proc Natl Acad Sci U S A 2001 (Malaria, Falciparum) : Antigen-specific IFN-gamma responses were detected by enzyme linked immunospot ( ELISPOT ) assays in all subjects to multiple 9- to 23-aa peptides containing class I and/or class II restricted epitopes, and were dependent on both CD8 ( + ) and CD4 ( + ) T cells
Cho et al., J Immunol 2001 : In this study, we demonstrated that non-APC-specific gene expressions induced significant CD8 ( + ) CTL and IFN-gamma producing cells and Ab responses, whereas APC-specific gene expressions led to moderate CTL and IFN-gamma-producers , but no Ab responses
Tau et al., J Immunol 2001 : Regulation of IFN-gamma signaling is essential for the cytotoxic activity of CD8 ( + ) T cells
Kostense et al., Blood 2002 (Acquired Immunodeficiency Syndrome...) : In a longitudinal study including 16 individuals infected with HIV-1, we studied both the number and function of HIV-specific CD8 ( + ) T cells by comparing HLA-peptide tetramer staining and peptide induced interferon-gamma (IFN-gamma) production
Kelso et al., Int Immunol 2002 : When CD44 ( low ) CD62L ( high ) CD8 ( + ) lymph node T cells were activated with IL-2 and immobilized antibodies to CD3, CD8 and CD11a, expression of perforin, granzyme B and IFN-gamma mRNAs was induced by day 2, and increased in parallel with perforin dependent cytolytic activity
Dunn et al., J Infect Dis 2002 : To study the dynamics of cytomegalovirus ( CMV ) immunity in healthy immunocompetent hosts, interferon-gamma producing CD4 and CD8 T cell responses in the presence or absence of CMV antigens were measured from 15 CMV-seropositive donors and 13 CMV-seronegative donors
Fadel et al., J Immunol 2002 (Retroviridae Infections...) : Despite the induction of significant anti-viral CD8+ mediated cytotoxic T lymphocyte and IFN-gamma responses, initial neonatal priming led to a lower frequency of virus-specific T cells compared with adult priming
Pien et al., J Immunol 2002 (Lymphocytic Choriomeningitis) : The kinetics of CD8 T cell IFN-gamma responses as they occur in situ are defined here during lymphocytic choriomeningitis virus ( LCMV ) infections, and a unique mechanism for the innate cytokines IFN-alphabeta and IL-18 in promoting these responses is defined ... Production of IFN-gamma was MHC class I/CD8 dependent , but did not require IL-12, NK cells, TCR-gammadelta T cells, MHC class II, or CD4 T cells
Wang et al., Int J Cancer 2003 (Carcinoma...) : Depletion of CD8 ( + ) T cells suppressed the production of interferon-gamma
Segel et al., Am J Physiol Lung Cell Mol Physiol 2003 (Pulmonary Fibrosis) : CD4+, CD8+ , and natural killer cells each contributed significantly to IFN-gamma production
Liu et al., J Immunol 2003 : IL-10 mediates suppression of the CD8 T cell IFN-gamma response to a novel viral epitope in a primed host
Raez et al., Cancer Gene Ther 2003 (Carcinoma, Non-Small-Cell Lung...) : Induction of CD8 T-cell-Ifn-gamma response and positive clinical outcome after immunization with gene modified allogeneic tumor cells in advanced non-small-cell lung carcinoma ... The study demonstrates that CD8 Ifn-gamma responses against nonimmunogenic or immunosuppressive tumors can be evoked by cellular vaccines even at advanced stages of disease
Ott et al., J Immunol Methods 2004 (Diabetes Mellitus, Type 1...) : CD4 and CD8 IFN-gamma responses to viral ( hepatitis C ) and autoimmune antigens ( islet cell ) were tested in 10 hepatitis C and 8 type 1 diabetic as well as healthy control subjects
Hallez et al., Cancer Immunol Immunother 2004 (Cervical Intraepithelial Neoplasia...) : Five vaccinated patients ( 71 % ) showed significantly increased IFN-gamma CD8+ cell responses upon PD-E7 stimulation
Herath et al., Parasite Immunol 2003 (Leishmaniasis, Cutaneous) : Cross-talk between CD8 ( + ) and CD4 ( + ) T cells in experimental cutaneous leishmaniasis : CD8 ( + ) T cells are required for optimal IFN-gamma production by CD4 ( + ) T cells
Kitchen et al., Proc Natl Acad Sci U S A 2004 (HIV Infections) : Here, we report that the CD4 molecule plays a direct role in CD8 ( + ) T cell function by modulating expression of IFN-gamma and Fas ligand, two important CD8 ( + ) T cell effector molecules
Sheth et al., AIDS 2004 (HIV Infections) : We therefore examined the association between systemic HIV-specific IFN-gamma CD8 responses and viral load in the semen and blood of HIV infected men
Edwards et al., Eur J Immunol 2005 (Cryptococcosis...) : CD4 ( + ) and CD8 ( + ) T cells producing IFN-gamma increase in frequency, while those producing IL-5 decrease
Chen et al., Eur J Immunol 2005 (Dermatitis, Contact...) : However, by contrast with CCL5/RANTES, the diminished levels of IFN-gamma were likely due to the decreased number of skin infiltrating CD8 ( + ) T cells, since IFN-gamma production by antigen stimulated CD8 ( + ) T cells was comparable between wild-type and IL-15Ralpha ( -/- ) mice
Ramadan et al., Clin Exp Immunol 2005 : Cytotoxic activity and interferon (IFN)-gamma production were mediated exclusively by CD8 ( + ) T cells in response to pool pulsed targets
Miyagi et al., Clin Exp Immunol 2005 (Cryptococcosis...) : The IFN-gamma synthesis in BALF was inhibited by depletion of CD8 ( + ) and CD4 ( + ) T cells on days 7 and 14 after infection, respectively, but not by depletion of NK and gammadelta T cells
Gregori et al., J Exp Med 2005 : Similarly, CD8 ( + ) T cell lines specific for the influenza A matrix protein derived peptide ( MP.58-66 ) generated in the presence of chA6 mAb were anergic and suppressed IFN-gamma production by MP.58-66-specific effector CD8 ( + ) T cells
Worgall et al., J Clin Invest 2005 (Pseudomonas Infections) : AdZ.Epi8 induced Epi8-specific IFN-gamma positive CD4 and CD8 T cell responses and resulted in protection against a lethal pulmonary challenge with agar encapsulated P. aeruginosa
Bekker et al., AIDS 2005 (Cytomegalovirus Infections...) : Despite these increases, the CMV-specific IFN-gamma producing CD8 T cell response was diminished, which could explain the inability to suppress CMV completely in 41 % of HIV-1 infected children
Suradhat et al., Vet Immunol Immunopathol 2005 (Classical Swine Fever) : The CD4 ( - ) CD8 ( + ) cells were major IFN-gamma producing cells in vaccinated pigs, while both CD4 ( + ) CD8 ( + ) and CD4 ( - ) CD8 ( + ) populations contributed to the IFN-gamma production in the control group
Antonis et al., Vaccine 2006 (Respiratory Syncytial Virus Infections) : Functional IFN-gamma+ CD8 responses were slightly higher in the FI-bRSV vaccinated animals
Fogg et al., J Immunol 2006 (Herpesviridae Infections...) : rhBZLF1-specific IFN-gamma ELISPOT responses ranging between 56 and 3070 spot forming cells/10 ( 6 ) PBMC were detected in 36 of 57 ( 63 % ) rhesus macaques and were largely mediated by CD8 ( + ) T lymphocytes
Kapogiannis et al., AIDS Res Hum Retroviruses 2006 (HIV Infections...) : Among untreated patients with increased viral load there was a constant IFN-gamma CD8 response but a declining IFN-gamma CD4 response
Ramirez-Montagut et al., J Immunol 2006 (Disease Progression...) : Rejection requires CD4+, CD8+ , and NK1.1+ cells and is dependent on IFN-gamma and Fas ligand and independent of perforin
Blachère et al., J Immunol 2006 : Concerning the interaction between CD4 ( + ) T cells and DCs, we tested the hypothesis that CD40 engagement on DCs is critical for IL-12p70 ( IL-12 ) production and subsequent stimulation of IFN-gamma release by CD8 ( + ) T cells
Yonkers et al., J Infect Dis 2006 (HIV Infections...) : We measured CD4- and CD8-specific interferon- gamma responses to hepatitis C virus ( HCV ) peptide pools in subjects with chronic HCV monoinfection ( n=14 ), in subjects with chronic HCV/HIV coinfection ( n=15 ), and in healthy control subjects ( n=10 ) by enzyme linked immunospot assay in the presence and absence of CD28 costimulation
Liu et al., J Immunol 2006 : Overcoming original antigenic sin to generate new CD8 T cell IFN-gamma responses in an antigen experienced host
Fuse et al., J Virol 2006 : During long-term immune surveillance, the virus-specific CD8 ( + ) T cells were impaired in IFN-gamma production and secondary expansion and exhibited an altered phenotype
Alimonti et al., Immunol Cell Biol 2006 (HIV Infections) : Overall, many of the HIV ( ES ) women possess a HIV-1 p24-specific CD8+ IFN-gamma response , providing evidence to the specificity needed for an effective HIV vaccine
Kosaka et al., Cancer Sci 2006 : The fact that IL-12 administration in vivo caused the generation of ASGM1 ( + ) CD8 ( + ) killer T cells in an IFN-gamma dependent manner further indicated a physiological significance of ASGM1 ( + ) CD8 ( + ) central memory-type T cells in IL-12 induced immunoregulation for the therapy of tumors and infectious diseases
Ortega et al., Res Vet Sci 2007 (Chlamydophila Infections) : An effective vaccine against C. abortus must induce a Th1-like specific immune response, which is characterized by the early production of IFN-gamma and the activation of CD8 ( + ) T cells
Russell et al., J Acquir Immune Defic Syndr 2007 : Net cumulative HIV-specific CD8 IFNgamma ELISpot assay responses were 13 % ( 95 % CI : -1 % to 26 % ) for recipients of vCP1452 alone and 16 % ( 95 % CI : 2 % to 29 % ) for recipients of vCP1452 plus rgp120
Hokeness et al., J Virol 2007 (Cytomegalovirus Infections) : Furthermore, CXCR3 functions augmented the hepatic accumulation of CD8 T-cell IFN-gamma responses to MCMV
Dobaño et al., Mol Immunol 2007 (Malaria) : Mutation of the P2 but not P9 or P10 anchor residues decreased protection and completely abrogated the antigen-specific CD8+ CTL activity and CD8+ dependent IFN-gamma responses to the immunodominant CD8+ epitope and overlapping CD8+/CD4+ epitope
Asavaroengchai et al., Biol Blood Marrow Transplant 2007 (Graft vs Host Disease) : These data show that IFN-gamma negatively regulates the CD8 T cell response by inhibiting cell division and promoting cell death and suggest that blockade of IFN-gamma could augment the severity of GVHD in patients undergoing allo-HCT
Rodriguez et al., J Gen Virol 2007 (Chronic Disease...) : In vitro stimulation of whole-blood cultures with recombinant gp120 ( rgp120 ) resulted in enhanced IFN-gamma production predominantly by the CD3 ( - ) CD8 ( + ) subset of NK cells, and addition of anti-IL-15 to the system decreased IFN-gamma production
Ngai et al., Infect Immun 2007 (Disease Models, Animal...) : By using major histocompatibility complex class II-deficient or CD4-deficient mice, we found that the lack of CD4 T cells did not negatively affect primary or secondary CD8 T-cell IFN-gamma responses ... Moreover, during mycobacterial infection, CD8 T-cell IFN-gamma responses and activation are independent of CD4 T-cell activation
Osorio et al., Virus Res 2007 : IFN-gamma expression by CD4 ( + ) T cells was CD8 ( + ) T cells dependent
McNicol et al., Eur J Immunol 2007 : Using anti-CD8alpha and anti-CD8beta antibodies, we found that cytotoxicity and IFN-gamma production by high but not by low avidity CTL was strongly CD8 dependent
Spadaro et al., Cancer Res 2007 (Adenocarcinoma...) : Thus, the inhibition of distant tumors by oral TLF seems to be mediated by an IFN-gamma dependent enhancement of CD8 ( + ) T- and NKT cell activity initiated within the intestinal mucosa
Messingham et al., J Immunol 2007 (Listeriosis) : Whether IFN-gamma contributes to the per-cell protective capacity of memory CD8 ( + ) T cells against Listeria monocytogenes ( LM ) has not been formally tested
Isogai et al., Immunology 2007 (Asthma...) : We have previously shown that CD8 ( + ) gammadelta T cells decrease late allergic airway responses, airway eosinophilia, T helper 2 cytokine expression and increase interferon-gamma (IFN-gamma) expression
Saha et al., J Immunol 2007 (Disease Susceptibility...) : Both CD4 ( + ) and CD8 ( + ) T cells were involved in IFN-gamma and IL-10 production
Niederkorn et al., Curr Opin Immunol 2008 (Multiple Sclerosis...) : In many cases, IFN-gamma is required for either the induction or expression of CD8 ( + ) T regs
Rifa'i et al., Int Immunol 2008 : CD8 ( + ) CD122 ( + ) Treg effectively suppressed the IFN-gamma production of the target cells of syngeneic mouse strains but not of allogeneic mouse strains with incompatible MHC
Chakravarty et al., Infect Immun 2008 : However, the requirement for CD8 ( + ) T-cell mediated IFN-gamma production in protective immunity to this pathogen has not been directly tested
Wells et al., J Immunol 2008 (Melanoma, Experimental) : Immunization with two or more TLR agonists, anti-CD40, IFN-gamma , and surfactant were sufficient to drive unprecedented levels of CD8 response to peptide or protein Ag and highly polarized Th1 CD4 responses
Björck et al., J Immunol 2008 : IC-loaded pDC stimulate CD4 ( + ) T cells to proliferate and secrete a mixture of IL-4 and IFN-gamma, and they induce CD8 ( + ) T cells to secrete IL-10 as well as IFN-gamma ... In contrast, IC-loaded myDC induce both CD4 ( + ) and CD8 ( + ) T cells to secrete mainly IFN-gamma
Kutscher et al., AIDS research and therapy 2008 : The intracellular detection of MIP-1beta enhances the capacity to detect IFN-gamma mediated HIV-1-specific CD8 T-cell responses in a flow cytometric setting providing a sensitive alternative to the ELISPOT
Apte et al., Proc Natl Acad Sci U S A 2008 : Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells
Onishi et al., Br J Urol 1991 (Kidney Neoplasms) : The effect of IFN-gamma on TIL was an increase in CD3 ( pan-T cells ), especially an increase in CD8 ( cytotoxic/suppressor-T cells )
Balkow et al., Exp Dermatol 2009 : When compared with untreated DC or DC treated with anti-CD40 alone, DC matured with anti-CD40 plus IL-12 and IL-18 expressed significantly more IFN-gamma and IL-12, induced enhanced CD8 ( + ) T-cell proliferation, prolonged synaptic interaction with T cells and increased CD8 ( + ) T-cell mediated cytotoxicity
Rutenfranz et al., Scand J Immunol 1991 : In further studies, depletion of T-cell subsets showed that CD3+, CD4+, CD8+ , CD29+ and CD45RA+ cells were involved in IFN-gamma production after mitogenic stimulation
Ascon et al., Kidney Int 2009 (Kidney Diseases...) : Depletion of CD4 ( + ) and CD8 ( + ) T cells before ischemia caused less medullary damage and reduced kidney IFN-gamma expression, whereas their depletion following ischemia increased kidney IL-1beta ; however, depletion of these cells had no effect on histological damage to the kidney
Robinson et al., J Immunol 2009 (Disease Models, Animal...) : We conclude that liver damage in this model of fulminant autoimmune hepatitis is driven by CD4 ( + ) T cell production of IFN-gamma , is independent of both CD8 ( + ) T cells and the Fas ligand/Fas pathway, and is not explained by a lack of PD-L1 expression
Liu et al., J Virol 2009 (Disease Models, Animal...) : In addition, M ( 209-223 ) peptide activated CD4 T cells reduced IFN-gamma and IL-2 production in M- and M2-specific CD8 T-cell responses to D ( b ) -M ( 187-195 ) and K ( d ) -M2 ( 82-90 ) peptides more than M2 ( 25-39 ) peptide stimulated CD4 T cells
Komai-Koma et al., Eur J Immunol 2009 : Moreover, CD8 ( + ) CD45RO ( + ) memory T cells constitutively expressed TLR4 and markedly enhanced IFN-gamma production when stimulated with LPS
Wong et al., J Immunol 2009 : IL-12p70 production was produced predominantly by CD8alpha ( + ) DCs and plasmacytoid DCs, and mediated by CD8 T cell derived cytokines IFN-gamma , GM-CSF, TNF-alpha, and surface CD40L
Takeda et al., J Immunol 2009 (Asthma...) : Using adoptive transfer experiments, we found that suppression of AHR was mediated by Ag-specific CD8 ( + ) T cells and was dependent on IFN-gamma production by the transferred T cells
Yuan et al., Eur J Cancer Prev 2009 (Breast Neoplasms) : We also found that CD4 positive and CD8 positive lymphocytes were detected only in tumors grown in rBCG-MVNTR4/8-CSF immunized animals, and strong IFN-gamma responses were induced by immunization with rBCG-MVNTR4-CSF and rBCG-MVNTR8-CSF vaccines
Todryk et al., Immunology 2009 : We observed a significant correlation between IFN-gamma responses to CD4-stimulatory, but not to CD8-stimulatory , recall antigens measured by these assays, suggesting a divergence in regulation
Park et al., J Leukoc Biol 2009 (Alveolitis, Extrinsic Allergic) : Moreover, IL-10 production of CD4 ( + ) CD25 ( + ) T ( reg ) cells and direct contact between CD4 ( + ) CD25 ( + ) T ( reg ) cells and CD4 ( + ) or CD8 ( + ) T cells in BALF resulted in reduced IFN-gamma production
Tuettenberg et al., Exp Dermatol 2010 : Furthermore, stimulation of CD8 ( + ) T cells by peptide loaded CD40L-DC resulted in a substantial reduction of antigen-specific IFN-gamma production
Sercan et al., J Immunol 2010 (Lymphopenia) : Although its antimicrobial effector functions are well described, less is known about the mechanisms by which IFN-gamma regulates CD8 ( + ) T cell homeostasis
Freeman et al., J Immunol 2010 (Pulmonary Disease, Chronic Obstructive) : In vitro stimulation of lung CD8 ( + ) T cells with IL-18 plus IL-12 markedly increased production of IFN-gamma and TNF-alpha, whereas IL-15 stimulation induced increased intracellular perforin expression
Contreras et al., J Immunol 2010 : Compared to CD26 ( - ) DCs, the sheep CD26 ( + ) DCs show 1 ) potent stimulation of allogeneic naive CD8 ( + ) T cells with high selective induction of the Ifngamma and Il22 genes ; 2 ) dominant efficacy in activating specific CD8 ( + ) T cells against exogenous soluble Ag ; and 3 ) selective expression of functional pathways associated with high capacity for Ag cross-presentation
Hodgkin et al., Cell Immunol 1990 : Interferon-gamma (IFN-gamma) caused almost complete inhibition of the CD4+/CD8- response but had no measurable effect on the growth of CD4-/CD8+ or CD4-/CD8- populations
Connick et al., J Acquir Immune Defic Syndr 2011 (HIV Infections) : HIV-specific CD8+ interferon-gamma responses increased after 48 weeks of ART ( P = 0.03 ), but failed to predict virologic success ( P = 0.18 )
Brisbin et al., Benef Microbes 2012 : The results demonstrated that chicken CD4+ and CD8+ T-cells express TLR21 and that the various isolates of lactobacilli differentially induces the expression of interleukin 10, interferon-gamma and transforming growth factor beta
Siegel et al., Cell Immunol 1988 : It is concluded that ( i ) IFN-gamma augmented activation of T cells in human MLC, ( ii ) IFN-gamma exerted effects directly on T cells, and ( iii ) IFN-gamma preferentially augmented CD8+ cell activation
Dieli et al., J Immunol 1997 (Dermatitis, Contact) : In fact, the production of IFN-gamma was due to a CD8+ , gamma delta+ T cell, while proliferation and IL-2 production required the presence of a CD4+, alpha beta+ T cell
Dieli et al., Cytokine 1996 : This production of IFN-gamma is both antigen-specific and genetically ( MHC ) -restricted and is due to both CD8+ and CD4+ T cells
Vaidya et al., J Exp Med 1997 : Here, we isolate the gene for TLTF and demonstrate that the recombinant version of TLTF specifically induces CD8 ( + ), but not CD4 ( + ), T cells to secrete IFN-gamma
Connelly et al., Infect Immun 1997 (Malaria) : The dominance of type 1 CD8 cell IFN-gamma responses is consistent with a role for this T-cell population in immunity to liver-stage Plasmodium falciparum in humans
Su et al., J Immunol 1998 (Lymphocytic Choriomeningitis) : CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections : requirements for IL-2