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CDC42 — PLD1

Pathways - manually collected, often from reviews:

• NCI Pathway Database CDC42 signaling events: CDC42/GTP complex (CDC42) → PLD1 (PLD1) (modification, activates) Walker et al., J Biol Chem 2000*
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PLD1 — CDC42 (direct interaction, pull down) Walker et al., J Biol Chem 2000*
• IRef Biogrid Interaction: PLD1 — CDC42 (physical association, affinity chromatography technology) Walker et al., J Biol Chem 2000*
• IRef Hprd Interaction: PLD1 — CDC42 (in vivo) Walker et al., J Biol Chem 2000*
• IRef Hprd Interaction: PLD1 — CDC42 (in vitro) Walker et al., J Biol Chem 2000*
• IRef Ophid Interaction: PLD1 — CDC42 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Walker et al., J Biol Chem 2000 : Activation of phospholipase D1 by Cdc42 requires the Rho insert region ... Although binding of Cdc42 to PLD1 does not require geranylgeranylation, activation of PLD1 is dependent on this lipid modification of Cdc42 ... Specific point mutations in the switch I region of Cdc42 abolish binding to and, therefore, activation of PLD1 by Cdc42
Walker et al., J Biol Chem 2002 : To understand the mechanism of the insert mediated activation of PLD1 by Cdc42 and to develop reagents to study Cdc42 activated PLD1 in cellular signaling events, we have undertaken a mutational analysis of the Rho insert region of Cdc42 and examined the specificity of the insert helix requirement in the other Rho family members, RhoA and Rac1
Fang et al., Curr Biol 2003 : PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1 ... In this study, we set out to test the hypotheses that phospholipase D 1 (PLD1) is an upstream regulator of mTOR and that the previously reported S6K1 activation by Cdc42 is mediated by PLD1
Yoon et al., Biochem Biophys Res Commun 2006 : To examine the effect of Cdc42 on PLD activation and neurite outgrowth, we transfected dominant negative Cdc42 ( Cdc42N17 ) and constitutively active Cdc42 ( Cdc42V12 ) into neural stem cells, respectively ... On the other hand, Cdc42V12 increased both PLD activity and neurite outgrowth, suggesting that active state of Cdc42 is important in upregulation of PLD activity which is responsible for the increase of neurite outgrowth
Harkins et al., FEMS Yeast Res 2008 : Constitutively activated Cdc42p stimulates PLD1 activity
Bae et al., J Biol Chem 1998 : In conclusion, the present study shows that conserved amino acids in the switch I region of RhoA are major PLD interaction sites and that residues in the switch II and internal regions are responsible for the differential activation of PLD by RhoA and Cdc42Hs