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PRKCA — RHOA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of DVL2-DVL3-PRKCA-RHOA → WNT3A (increases)
  Evidence: PKCa, PCKb, and PKCmu were associated with both Dvl-2 (Figure 8A) and Dvl-3 (Figure 8B), suggesting that several PKCs are likely included in the Dvl/RhoA complex.
• KEGG Tight junction: PRKCA/PRKCB/PRKCD/PRKCE/PRKCG/PRKCH/PRKCQ → RHOA (protein-protein, activation)
• NCI Pathway Database Syndecan-4-mediated signaling events: RhoA (RHOA) → PKC alpha (PRKCA) (positive regulation of focal adhesion formation, collaborate) Thodeti et al., J Biol Chem 2003*
  Evidence: mutant phenotype, assay
• NCI Pathway Database PAR1-mediated thrombin signaling events: PKC alpha (PRKCA) → RHOA/GDP complex (RHOA) (modification, activates) Singh et al., J Biol Chem 2007*
  Evidence: assay
• NCI Pathway Database PAR1-mediated thrombin signaling events: PKC alpha (PRKCA) → RhoA/GDP/RHOGDI complex (ARHGDIA-RHOA) (modification, activates)
  Singh et al., J Biol Chem 2007*
  Evidence: assay
• NCI Pathway Database Thromboxane A2 receptor signaling: RhoA/GTP/ROCK1 complex (RHOA-ROCK1) → Typical PKCs (PRKCD/PRKCG/PRKCB/PRKCQ/PRKCB/PRKCA/PRKCE/PRKCH) (muscle contraction, activates)
  Nakahata et al., Life Sci 2000, Bolla et al., J Vasc Res 2002, Fu et al., FEBS Lett 1998
  Evidence: mutant phenotype, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: PRKCA — RHOA (in vivo) Slater et al., Biochemistry 2001*
• IRef Ophid Interaction: PRKCA — RHOA (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: PRKCA — RHOA (aggregation, confirmational text mining) Slater et al., Biochemistry 2001*

Text-mined interactions from Literome

Khare et al., Am J Physiol 1999 : PTx did not, however, block the membrane translocation of RhoA induced by 1,25 ( OH ) 2D3 or inhibit the stimulation of PKC-alpha by TPA
Houle et al., J Leukoc Biol 1999 : Whereas fMLP recruited all three proteins to membranes, V4+-OOH only elicited RhoA translocation and PMA induced ARF and PKCalpha translocation
Meacci et al., FEBS Lett 2000 : Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate induced Rho A activation in C2C12 myoblasts
Slater et al., Biochemistry 2001 : It was found that the activity of PKCalpha was potently enhanced by RhoA and Cdc42 and to a lesser extent by Rac1, whereas the effects on the activities of PKCbetaI, -betaII, -gamma, -delta, -epsilon, and -zeta were much reduced
Dovas et al., J Cell Sci 2006 : Furthermore, inhibition of PKCalpha could block the increase in the GTP levels of RhoA induced by clustering of syndecan-4 at the cell surface
Singh et al., J Biol Chem 2007 : Our results demonstrate that Galphaq activation of TRPC6 signals the activation of PKCalpha , and thereby induces RhoA activity and endothelial cell contraction