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ERBB2 — PAK1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
He et al., Cancer J 2001
(Sarcoma, Experimental) :
Using four distinct, cell-permeable, and highly specific inhibitors, namely WR-PAK18, which blocks the PAK-PIX interaction ; AG 1478, which inhibits ErbB1 kinase activity ; and AG 825 or AG 879, which inhibits ErbB2 kinase activity, we demonstrate that ( 1 ) the
PAK-PIX interaction is essential for v-Ha-RAS induced malignant transformation ; ( 2 ) v-Ha-RAS
requires not only ErbB1 but also
ErbB2 , which are activated through two independent autocrine pathways to induce both the PIX/Rac/CDC42 dependent PAK activation and malignant transformation in vitro ; and ( 3 ) a combination of AG 879 and the Src family kinase-specific inhibitor PP1 suppresses almost completely the growth of RAS induced sarcomas in nude mice
Arias-Romero et al., Oncogene 2010
(Breast Neoplasms...) :
In this study, we asked if
ErbB2 expression correlates with Pak1 and Erk activity in human breast cancer specimens, and if
Pak1 signaling is
required for ErbB2 transformation in a three-dimensional ( 3D ) in vitro setting and in xenografts ... We found a correlation between
ErbB2 expression and
activation of
Pak in estrogen receptor positive human breast tumor samples and observed that in 3D cultures, activation of Rac-Pak1 pathway by ErbB2 homodimers induced growth factor independent proliferation and promoted disruption of 3D mammary acinar-like structures through activation of the Erk and Akt pathways