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CDC25A — CDK1

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: CDC25A → CDK1 (protein-protein, dephosphorylation)
• KEGG Progesterone-mediated oocyte maturation: CDC25A/CDC25B/CDC25C → CDK1 (protein-protein, activation)
• Reactome Reaction: CDK1 → CDC25A (reaction) Mailand et al., Science 2000*, Mailand et al., EMBO J 2002*, Strausfeld et al., Nature 1991*, Strausfeld et al., J Biol Chem 1994*, Honda et al., FEBS Lett 1993*
• WikiPathways Cell Cycle: CDC25A → CDK1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: CDK1 — CDC25A (in vivo) Mailand et al., EMBO J 2002*
• IRef Hprd Interaction: CDK1 — CDC25A (in vitro) Mailand et al., EMBO J 2002*

Text-mined interactions from Literome

Chow et al., Mol Biol Cell 2003 : DNA damage during the spindle-assembly checkpoint degrades CDC25A , inhibits cyclin-CDC2 complexes, and reverses cells to interphase
Huang et al., Cancer Res 1997 : Our results revealed that GL331 could facilitate the association of CDC 25A with Raf-1, resulting in the cascade of CDC 25A phosphatase activation and CDC 2 kinase activation , as well as related signaling pathways, and ultimately causing apoptosis in cancer cells