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IL6 — UCN

Text-mined interactions from Literome

Kohno et al., J Clin Endocrinol Metab 2001 (Arthritis, Rheumatoid...) : Urocortin stimulated IL-1beta and IL-6 secretion by human peripheral blood mononuclear cells in vitro
Kageyama et al., Endocrinology 2003 (MAP Kinase Signaling System) : In this cell line, both Ucn and Ucn II induced accumulation of intracellular cAMP via corticotropin releasing factor receptor type 2beta and also caused a significant increase in IL-6 output levels
Huang et al., Cardiovasc Res 2003 (Coronary Disease) : Stress induced IL-6 release may, therefore, be at least partly due to peripheral Ucn and/or CRH, with Ucn possibly overcompensation for CRH deficiency
Kageyama et al., Endocrinology 2006 : Urocortin induces interleukin-6 gene expression via cyclooxygenase-2 activity in aortic smooth muscle cells ... We previously found that both Ucn1 and -2 induced accumulation of intracellular cAMP via CRF ( 2beta ) receptor binding and significantly increased IL-6 secretion by A7r5 aortic smooth muscle cells ... In the present study, we investigated Ucn effects on IL-6 gene expression and IL-6 synthesis in A7r5 aortic smooth muscle cells
Kageyama et al., Peptides 2007 : Inhibitory effects of glucocorticoids on urocortin mediated increases in interleukin-6 gene expression in rat aortic smooth muscle cells ... We previously demonstrated that both Ucn1 and Ucn2 increased IL-6 output levels in A7r5 aortic smooth muscle cells ... In the present study, we extended observations on stress or hormone induced changes in IL-6 gene expression in the cardiovascular system, and determined the effects of glucocorticoids on Ucn mediated increases in IL-6 mRNA levels, protein levels, and gene transcription activity in A7r5 cells ... Ucn1 , Ucn2, and Ucn3 all increased IL-6 mRNA levels via CRF receptor type 2
Huang et al., J Mol Endocrinol 2009 : Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation ... Here, we show that neonatal rat cardiomyocytes express CRH-R2 by western blot analysis and Ucn induces interleukin-6 (IL-6) release in a time- and dose dependent fashion ... Ucn stimulates activation of ERK and p38 MAP kinases, while both MEK1 and p38 inhibitor block Ucn induced IL-6 release ... Ucn also activates nuclear factor kappa B (NF-kappaB) and a NF-kappaB inhibitor blocks Ucn induced IL-6 release ... Finally, the CRH-R antagonists alpha-helical ( 9-41 ) CRH and astressin-2B completely inhibit Ucn induced IL-6 release, as well as activation of ERK, p38, and NF-kappaB ... These findings indicate that Ucn induces IL-6 synthesis and release from neonatal rat cardiomyocytes
Agnello et al., Am J Physiol 1998 : In mice, UCN ( 1 microg/mouse sc ) significantly reduced lipopolysaccharide (LPS) induced serum tumor necrosis factor (TNF) and interleukin (IL)-1beta levels in vivo but did not affect serum IL-6