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EDN1 — IL6

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Kawamura et al., Bone 1999 : Involvement of p42/p44 MAP kinase in endothelin-1 induced interleukin-6 synthesis in osteoblast-like cells ... We previously reported that endothelin-1 induces synthesis of interleukin-6 (IL-6) via activation of protein kinase C in osteoblast-like MC3T3-E1 cells ... In the present study, we further investigated whether p42/p44 mitogen activated protein ( MAP ) kinase is involved in endothelin-1 induced IL-6 synthesis in these cells ... Endothelin-1 stimulated p42/p44 MAP kinase activation in a dose dependent manner in the range between 0.1 nmol/L and 0.1 micromol/L. PD98059, a specific inhibitor of the upstream kinase that activates p42/p44 MAP kinase, suppressed endothelin-1 induced IL-6 synthesis as well as endothelin-1 activated p42/p44 MAP kinase ... Calphostin C, a highly specific inhibitor of protein kinase C, suppressed endothelin-1 stimulated p42/p44 MAP kinase activation as well as endothelin-1 induced IL-6 synthesis ... These results strongly suggest that protein kinase C-dependent p42/p44 MAP kinase activation is involved in endothelin-1 induced IL-6 synthesis in osteoblast-like cells
Kawamura et al., Am J Physiol 1999 : We previously reported that endothelin-1 (ET-1) activates p42/p44 mitogen activated protein ( MAP ) kinase in osteoblast-like MC3T3-E1 cells and consequently induces synthesis of interleukin-6
Browatzki et al., Basic Res Cardiol 2000 : Endothelin-1 induces interleukin-6 release via activation of the transcription factor NF-kappaB in human vascular smooth muscle cells
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2002 : We previously showed that prostaglandin F ( 2alpha ) ( PGF ( 2alpha ) ) and endothelin-1 (ET-1) induce interleukin (IL)-6 through the activation of protein kinase C-dependent p44/p42 mitogen activated protein ( MAP ) kinase in osteoblast-like MC3T3-E1 cells
Shiu et al., Eur J Haematol 2002 (Anemia, Sickle Cell...) : The presence of interleukin-1 in the perfusion system, as a model for inflammatory cytokine effects, enhanced the overall amounts of released prostacyclin but did not affect the production of endothelin-1
Stankevicius et al., Medicina (Kaunas) 2003 (Arteriosclerosis...) : The synthesis of endothelin-1 is induced by hypoxia, thrombin, interleukin-1 , transforming growth factor-beta1, vasopressin, and catecholamines
Browatzki et al., Eur J Med Res 2005 (Vasculitis) : Endothelin-1 induces CD40 but not IL-6 in human monocytes via the proinflammatory transcription factor NF-kappaB
Böhm et al., Atherosclerosis 2007 : Vitamin C blocks vascular dysfunction and release of interleukin-6 induced by endothelin-1 in humans in vivo
Kolb et al., Z Gesamte Inn Med 1991 (Anoxia...) : The synthesis of endothelin 1 in the endothelial cells is stimulated by adrenaline, noradrenaline, angiotensin II, arginine-vasopressin, thrombine, interleukin 1 and hypoxia
Tokuda et al., FEBS Lett 2007 : ( - ) -Epigallocatechin gallate suppresses endothelin-1 induced interleukin-6 synthesis in osteoblasts : inhibition of p44/p42 MAP kinase activation
Boesen et al., American journal of physiology. Renal physiology 2008 : Interleukin-1beta, but not interleukin-6 , enhances renal and systemic endothelin production in vivo
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2008 : In addition, PGD2 additively induced IL-6 synthesis in combination with endothelin-1 which induces IL-6 synthesis through p38 MAP kinase regulated by Rho-kinase
Kanse et al., Life Sci 1991 : Interleukin-1 beta, Interleukin-6 and interleukin-8 at various doses did not affect endothelin secretion
Chai et al., Biochim Biophys Acta 2009 : Endothelin-1 stimulates interleukin-6 secretion from 3T3-L1 adipocytes
Bauer et al., PloS one 2011 (Anoxia...) : The loss of C3 attenuated the increase in interleukin-6 and intracellular adhesion molecule-1 expression in response to chronic hypoxia, but not endothelin-1 levels
Chai et al., Int J Obes Relat Metab Disord 2013 : Synergistic induction of interleukin-6 expression by endothelin-1 and cyclic AMP in adipocytes ... We have demonstrated previously that endothelin-1 (ET-1) may stimulate interleukin-6 (IL-6) release from 3T3-L1 adipocytes
Xin et al., Tokushima J Exp Med 1994 : We have reported that endothelin (ET)-1 activates interleukin (IL)-6 production in rat aortic endothelial cell line ( WAE-1 cell )
Agui et al., Blood 1994 (Second Messenger Systems) : Stimulation of interleukin-6 production by endothelin in rat bone marrow derived stromal cells
McMillen et al., Crit Care Med 1995 : Endothelin-1 increases intracellular calcium in human monocytes and causes production of interleukin-6 ... Endothelin-1 increased intracellular calcium in monocytes and caused production of IL-6
Stanková et al., J Cardiovasc Pharmacol 1995 : We investigated the effects of endothelin ( ET ) and thrombin on the production of interleukin 6 (IL-6) in human umbilical vein endothelial cells ( HUVECs )
Stankova et al., Am J Physiol 1996 : To examine the consequence of endothelin stimulation on cytokine production, we explored the effect of endothelin-1 (ET-1) on interleukin-6 (IL-6) gene expression
Mullol et al., Neuropeptides 1996 : Endothelin-1 induces GM-CSF, IL-6 and IL-8 but not G-CSF release from a human bronchial epithelial cell line ( BEAS-2B )
Ruetten et al., J Physiol Pharmacol 1997 : Endothelin-1 (ET-1) enhances the biosynthesis of interleukin-6 (IL-6) in endothelial cells and bone marrow derived stromal cells of the rat
Matsuno et al., Cell Signal 1998 : Involvement of protein kinase C activation in endothelin-1 induced secretion of interleukin-6 in osteoblast-like cells