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MAPK1 — RPS6KA4

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RPS6KA4 → MAPK1 (increases, MAPK1 Activity, RPS6KA4 Activity)
  Evidence: several downstream substrates of ERK1/2 kinase have been identified (Brunet & Pouyssegur, 1997), including p90 ribosomal S6 kinase (p90rsk, also known as MAPK-activated protein kinase (MAPKAP-K) 1; Zhao et al. 1996) and mitogen- and stress-activated kinases (MSK) 1 and 2 (Deak et al. 1998).
• KEGG Neurotrophin signaling pathway: MAPK1/MAPK3 → RPS6KA4/RPS6KA5 (protein-protein, activation)
• NCI Pathway Database ErbB1 downstream signaling: MSK1-2 (RPS6KA4/RPS6KA5) → Erk1-2-active (MAPK3/MAPK1) (modification, collaborate)
  Arthur et al., FEBS Lett 2000*, Gupta et al., J Biol Chem 2002*
  Evidence: assay
• NCI Pathway Database ErbB1 downstream signaling: Erk1-2-active (MAPK3/MAPK1) → MSK1-2-active (RPS6KA4/RPS6KA5) (modification, activates)
  Arthur et al., FEBS Lett 2000*, Gupta et al., J Biol Chem 2002*
  Evidence: assay
• WikiPathways Insulin Signaling: MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14 → RPS6KA4/RPS6KA3/RPS6KA6/RPS6KA5/RPS6KA1/RPS6KA2 (activation)
  
• WikiPathways Angiopoietin Like Protein 8 Regulatory Pathway: MAP2K1/MAP3K7/MAPK14/MAPK1/MAP2K2/MAP3K2/MAP3K6/MAPK8/MAP4K1/MAP3K11/MAP4K3/MAPK10/MAP2K7/MAP3K4/MAP3K1/MAP3K12/MAPK4/MAPK11/MAP4K5/MAPK6/MAP4K4/MAPK3/MAP3K14/MAPK12/MAP2K5/MAP2K4/MAPK13/MAP3K5/MAPK9/MAPK7/MAP3K3/MAP3K9/MAP3K8/MAP2K6/MAP3K13/MAP4K2/MAP2K3/MAP3K10/MINK1 → RPS6KA5/RPS6KA6/RPS6KA4/RPS6KA1/RPS6KA2/RPS6KA3 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RPS6KA4 — MAPK1 (physical association, affinity chromatography technology) Tomás-Zuber et al., J Biol Chem 2001*
• IRef Biogrid Interaction: RPS6KA4 — MAPK1 (direct interaction, pull down) Tomás-Zuber et al., J Biol Chem 2001*
• IRef Hprd Interaction: RPS6KA4 — MAPK1 (in vitro) Deak et al., EMBO J 1998
• IRef Hprd Interaction: RPS6KA4 — MAPK1 (in vivo) Deak et al., EMBO J 1998
• IRef Ophid Interaction: RPS6KA4 — MAPK1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005