UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to RAD1

CHEK1 — RAD1

Pathways - manually collected, often from reviews:

NCI Pathway Database ATR signaling pathway: RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN) → RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN) (modification, collaborate)
Liu et al., Genes Dev 2000, Zhao et al., Mol Cell Biol 2001, Zou et al., Genes Dev 2002, Zou et al., Science 2003, Liu et al., Mol Cell Biol 2006, Wang et al., Mol Cell 2006, Unsal-Kaçmaz et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Lindsey-Boltz et al., J Biol Chem 2009, Kemp et al., J Biol Chem 2010, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database ATR signaling pathway: RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN) → CHK1 (CHEK1) (modification, collaborate) Liu et al., Genes Dev 2000, Zhao et al., Mol Cell Biol 2001, Zou et al., Genes Dev 2002, Zou et al., Science 2003, Liu et al., Mol Cell Biol 2006, Wang et al., Mol Cell 2006, Unsal-Kaçmaz et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Lindsey-Boltz et al., J Biol Chem 2009, Kemp et al., J Biol Chem 2010, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database ATR signaling pathway: RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN) → CHK1 (CHEK1) (modification, collaborate) Liu et al., Genes Dev 2000, Zhao et al., Mol Cell Biol 2001, Zou et al., Genes Dev 2002, Zou et al., Science 2003, Liu et al., Mol Cell Biol 2006, Wang et al., Mol Cell 2006, Unsal-Kaçmaz et al., Mol Cell Biol 2007, Delacroix et al., Genes Dev 2007, Choi et al., Proc Natl Acad Sci U S A 2007, Lindsey-Boltz et al., J Biol Chem 2009, Kemp et al., J Biol Chem 2010, Choi et al., Proc Natl Acad Sci U S A 2010
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database ATR signaling pathway: YWHAZ (YWHAZ) → RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN) (modification, activates)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database ATR signaling pathway: RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN) → CHK1 (CHEK1) (modification, collaborate) Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database ATR signaling pathway: RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-TIMELESS-TIPIN) → RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN) (modification, collaborate)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database ATR signaling pathway: CHK1 (CHEK1) → RPA/ATR/ATRIP/RAD17/RFC2-5/9-1-1/TopBP1/CEP164/TIMELESS/TIPIN/CLASPIN/CHK1 complex (RAD17-RFC2-RFC3-RFC4-RFC5-RPA1-RPA2-RAD9A-RAD1-HUS1-ATR-ATRIP-TOPBP1-CEP164-CLSPN-CHEK1-TIMELESS-TIPIN) (modification, collaborate)
Jiang et al., J Biol Chem 2003, Smits et al., Curr Biol 2006
Evidence: mutant phenotype, assay, physical interaction
WikiPathways miRNA Regulation of DNA Damage Response: Complex of RAD9A-HUS1-RAD1 → CHEK1 (activation)
WikiPathways ATR Signaling: RAD9B/RAD1/RAD9A/HUS1/RPA1/RPA1/RPA1/RPA1/RPA1/ATR/ATRIP/TOPBP1 → CHEK1 (activation)
WikiPathways DNA Damage Response: Complex of RAD9A-HUS1-RAD1 → CHEK1 (activation)