◀ Back to FAS
DAXX — FAS
Pathways - manually collected, often from reviews:
-
BioCarta fas signaling pathway (cd95):
FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG)
→
FAF1
(modification, collaborate)
-
BioCarta fas signaling pathway (cd95):
FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG)
→
FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10)
(modification, collaborate)
-
BioCarta fas signaling pathway (cd95):
FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG)
→
PTPN13
(modification, collaborate)
-
BioCarta fas signaling pathway (cd95):
FAF1
→
FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10)
(modification, collaborate)
-
BioCarta stress induction of hsp regulation:
DAXX
→
FAS L/FAS/DAXX complex (FASLG-FAS-DAXX)
(modification, collaborate)
-
BioCarta stress induction of hsp regulation:
DAXX
→
FAS L/FAS complex (FASLG-FAS)
(modification, collaborate)
-
BioCarta stress induction of hsp regulation:
FAS L/FAS/DAXX complex (FASLG-FAS-DAXX)
→
FAS L/FAS complex (FASLG-FAS)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5)
→
JNKK1 (MAP2K4)
(modification, activates)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX complex (FASLG-FAS-DAXX)
→
TNFSF6 (FASLG)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX complex (FASLG-FAS-DAXX)
→
FAS/DAXX complex (FAS-DAXX)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
TNFSF6 (FASLG)
→
FAS/DAXX complex (FAS-DAXX)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG)
→
Caspase 8/Caspase 8/Caspase 8/Caspase 8 complex (CASP8)
(modification, activates)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG)
→
I-FLICE (CFLAR)
(modification, activates)
-
BioCarta fas signaling pathway (cd95):
I-FLICE/RIP2 complex (CFLAR-RIPK2)
→
FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10)
(modification, activates)
-
BioCarta fas signaling pathway (cd95):
FAS/DAXX/FADD/Caspase 10 complex (FAS-DAXX-FADD-CASP10)
→
FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG)
(modification, collaborate)
-
BioCarta fas signaling pathway (cd95):
FAS/DAXX/FADD/Caspase 10 complex (FAS-DAXX-FADD-CASP10)
→
TNFSF6 (FASLG)
(modification, collaborate)
-
BioCarta fas signaling pathway (cd95):
FAS/DAXX/FADD/Caspase 10/FAS L complex (FAS-DAXX-FADD-CASP10-FASLG)
→
TNFSF6 (FASLG)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNFSF6 (FASLG)
→
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
TNFSF6 (FASLG)
→
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG)
(modification, collaborate)
-
BioCarta hiv-1 nef: negative effector of fas and tnf:
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8)
→
FAS/FADD/DAXX/ASK1/Caspase 8/Caspase 8/FAS L complex (FAS-FADD-DAXX-MAP3K5-CASP8-FASLG)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5)
→
MEK3 (MAP2K3)
(modification, activates)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5)
→
MEK6 (MAP2K6)
(modification, activates)
-
BioCarta fas signaling pathway (cd95):
FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10)
→
Caspase 7 (CASP7)
(modification, activates)
-
BioCarta fas signaling pathway (cd95):
FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10)
→
Caspase 7 (active) (CASP7)
(modification, activates)
-
BioCarta fas signaling pathway (cd95):
FAS L/FAS/DAXX/FADD/FAF1/Caspase 10 complex (FASLG-FAS-DAXX-FADD-FAF1-CASP10)
→
JNKK1 (MAP2K4)
(modification, activates)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5)
→
FAS L/FAS/DAXX complex (FASLG-FAS-DAXX)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5)
→
ASK1 (MAP3K5)
(modification, collaborate)
-
BioCarta keratinocyte differentiation:
FAS L/FAS/DAXX complex (FASLG-FAS-DAXX)
→
ASK1 (MAP3K5)
(modification, collaborate)
-
KEGG MAPK signaling pathway:
FAS
→
DAXX
(protein-protein, activation)
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP/cIAP2/TRAF1/TRAF2/Ask1/RAIDD complex (TNFRSF1A-CASP2-TNF-FADD-TRADD-RIPK1-MAP3K5-TRAF1-TRAF2-BIRC3-CRADD)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, activates)
Micheau et al., Cell 2003, Yang et al., Cell 1997, Saitoh et al., EMBO J 1998, Chang et al., Science 1998
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FASLG (FASLG)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8)
(modification, collaborate)
Juo et al., Curr Biol 1998
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FASLG (FASLG)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, collaborate)
Juo et al., Curr Biol 1998
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 complex (FAS-FADD-DAXX-MAP3K5-CASP8)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, collaborate)
Juo et al., Curr Biol 1998
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
c-FLIP (CFLAR)
→
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
(modification, inhibits)
Medema et al., EMBO J 1997
-
NCI Pathway Database HIV-1 Nef: Negative effector of Fas and TNF-alpha:
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG complex (FASLG-CASP8-MAP3K5-FAS-DAXX-FADD)
→
Caspase 8 (4 units) complex (CASP8)
(modification, activates)
Medema et al., EMBO J 1997
-
WikiPathways Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation:
DAXX
→
DAXX/FAS/FADD/FAF1/CASP10
(activation)
-
WikiPathways MAPK Signaling Pathway:
FAS
→
DAXX
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
FAS
—
DAXX
(physical association, affinity chromatography technology)
Kim et al., Biochem Biophys Res Commun 2003*
-
IRef Biogrid Interaction:
FAS
—
DAXX
(physical association, affinity chromatography technology)
Yang et al., Cell 1997
-
IRef Biogrid Interaction:
FAS
—
DAXX
(direct interaction, two hybrid)
Cermák et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
FAS
—
DAXX
(direct interaction, two hybrid)
Yang et al., Cell 1997
-
IRef Biogrid Interaction:
FAS
—
DAXX
(physical association, affinity chromatography technology)
Charette et al., Mol Cell Biol 2000*
-
IRef Biogrid Interaction:
FAS
—
DAXX
(direct interaction, pull down)
Perlman et al., Nat Cell Biol 2001*
-
IRef Biogrid Interaction:
FAS
—
DAXX
(physical association, affinity chromatography technology)
Ko et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
FAS
—
DAXX
(direct interaction, pull down)
Yang et al., Cell 1997
-
IRef Dip Interaction:
FAS
—
DAXX
(physical association, coimmunoprecipitation)
Kim et al., Biochem Biophys Res Commun 2003*
-
IRef Hprd Interaction:
FAS
—
DAXX
(two hybrid)
Charette et al., Ann N Y Acad Sci 2000*, Perlman et al., Nat Cell Biol 2001*, Yang et al., Cell 1997
-
IRef Hprd Interaction:
FAS
—
DAXX
(in vitro)
Charette et al., Ann N Y Acad Sci 2000*, Perlman et al., Nat Cell Biol 2001*, Yang et al., Cell 1997
-
IRef Hprd Interaction:
FAS
—
DAXX
(in vivo)
Charette et al., Ann N Y Acad Sci 2000*, Perlman et al., Nat Cell Biol 2001*, Yang et al., Cell 1997
-
IRef Intact Interaction:
FAS
—
DAXX
(physical association, pull down)
Charette et al., Mol Cell Biol 2000*
-
IRef Intact Interaction:
FAS
—
DAXX
(physical association, anti bait coimmunoprecipitation)
Ko et al., J Biol Chem 2001*
-
IRef Ophid Interaction:
FAS
—
DAXX
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Charette et al., Mol Cell Biol 2000
:
Here we show that phosphorylated dimers of HSP27 interact with
Daxx , a mediator of Fas induced apoptosis,
preventing the interaction of Daxx with both Ask1 and
Fas and blocking Daxx mediated apoptosis ... However, HSP27 blocked
Fas induced translocation of Daxx from the nucleus to the cytoplasm and Fas induced
Daxx- and Ask1 dependent apoptosis
Charette et al., Ann N Y Acad Sci 2000
:
Fas also activates a caspase independent pathway which correlates with Fas induced translocation of Daxx from the nucleus to the cytoplasm and
involves the interaction of
Daxx with Fas and Ask1
Markotic et al., J Gen Virol 2003
:
Although studies by others suggest that the nucleocapsid protein of Puumala virus interacts with the
Fas mediated apoptosis enhancer
Daxx at the gene expression level, it was determined that members of the TNF receptor superfamily did not contribute to the apoptosis observed in infected HEK293 cells
Chen et al., Mol Cell Biol 2003
:
In this study, we investigated the
role of
Daxx in
Fas- and stress induced apoptosis by small interfering RNA mediated Daxx silencing in mammalian cells ... These data strongly suggest that
Daxx may
inhibit Fas and stress mediated apoptosis by suppressing proapoptotic gene expression outside of PML domains
Chang et al., Science 1998
:
Fas activation
induced Daxx to interact with ASK1, which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity