Gene interactions and pathways from curated databases and text-mining

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DAXX — FAS

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Charette et al., Mol Cell Biol 2000 : Here we show that phosphorylated dimers of HSP27 interact with Daxx , a mediator of Fas induced apoptosis, preventing the interaction of Daxx with both Ask1 and Fas and blocking Daxx mediated apoptosis ... However, HSP27 blocked Fas induced translocation of Daxx from the nucleus to the cytoplasm and Fas induced Daxx- and Ask1 dependent apoptosis
Charette et al., Ann N Y Acad Sci 2000 : Fas also activates a caspase independent pathway which correlates with Fas induced translocation of Daxx from the nucleus to the cytoplasm and involves the interaction of Daxx with Fas and Ask1
Markotic et al., J Gen Virol 2003 : Although studies by others suggest that the nucleocapsid protein of Puumala virus interacts with the Fas mediated apoptosis enhancer Daxx at the gene expression level, it was determined that members of the TNF receptor superfamily did not contribute to the apoptosis observed in infected HEK293 cells
Chen et al., Mol Cell Biol 2003 : In this study, we investigated the role of Daxx in Fas- and stress induced apoptosis by small interfering RNA mediated Daxx silencing in mammalian cells ... These data strongly suggest that Daxx may inhibit Fas and stress mediated apoptosis by suppressing proapoptotic gene expression outside of PML domains
Chang et al., Science 1998 : Fas activation induced Daxx to interact with ASK1, which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity