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IL17A — MMP9
Text-mined interactions from Literome
Jovanovic et al., Arthritis Rheum 2000
(Arthritis, Rheumatoid) :
IL-17 induced
MMP-9 production in human monocyte/ macrophages was dependent on endogenous prostaglandin E2 synthesis and related to autocrine stimulation by TNFalpha, but was IL-1beta independent ...
IL-17 may
contribute to an unbalanced production of proinflammatory cytokines and
MMP-9 in diseased articular joint tissues by interacting with the macrophages in the rheumatoid synovium
Jovanovic et al., J Rheumatol 2001
:
IL-17 stimulated an increased level of
MMP-9 production relative to TIMP-1 production in monocytes/macrophages
Koshy et al., Ann Rheum Dis 2002
:
IL17 can, alone and synergistically in combination with other proinflammatory cytokines,
promote chondrocyte mediated
MMP dependent type II collagen release from cartilage
Bamba et al., J Gastroenterol 2003
:
In human colonic SEMFs,
MMP-3 secretion and MMP-3 mRNA expression were
induced by
IL-17 , IL-1beta, and TNF-alpha
Sylvester et al., Cell Signal 2004
:
ERK pathway inhibitors, PD98059 and U0126, down-regulated
IL-17 induced
MMP and ADAM-TS4 gene expression
Prause et al., Thorax 2004
:
The
effect of the T lymphocyte derived proinflammatory cytokine
interleukin (IL)-17 on
MMP-9 protein release and activity in the airways was studied in vivo and in vitro
Koenders et al., Arthritis Rheum 2005
(Arthritis, Experimental...) :
Moreover, local
IL-17 gene transfer
increased MMP expression without the need for IL-1, although IL-1 remained essential for part of the cartilage VDIPEN expression
Inatomi et al., Pancreas 2007
:
In human pancreatic myofibroblasts,
MMP-3 secretion and mRNA expression were
induced by
interleukin (IL)-17 , IL-1beta, and tumor necrosis factor (TNF) -alpha, respectively
Yagi et al., J Gastroenterol 2007
(Colitis) :
IL-17A and IL-17F significantly
enhanced IL-6, IL-8, LIF,
MMP-1 , and MMP-3 secretion ... Both
IL-17A and IL-17F
augmented IL-1beta induced secretion of IL-6, IL-8, LIF,
MMP-1 , and MMP-3
Agarwal et al., J Rheumatol 2008
(Arthritis, Rheumatoid...) :
Increased
IL-17 levels in ERA SF correlate with disease activity and this may be
due to increased production of
MMP and cytokines by IL-17
Liu et al., Exp Mol Pathol 2008
(Autoimmune Diseases...) :
Although
IL-17 induced a significant increase in MMP-2 and
MMP-9 gene expressions in cardiac fibroblasts, there was no change in TIMP-2 and TIMP-1 expressions
Cheng et al., Cell Mol Neurobiol 2009
:
Expression of
MMP-9 and cell migration
induced by
IL-17 and its related signal pathway were detected ...
IL-17 induced
MMP-9 expression was via p38 MAPK and ERK1/2 dependent NF-kappaB and AP-1 activation
Qiu et al., Immunobiology 2009
:
The
MMP-9 and GCP-2
induction by
IL-17 in MEF, and the absence of induction in L929 cells, were corroborated by gelatin zymography and ELISA, respectively
Liu et al., Journal of neuroinflammation 2012
(Pain) :
Inhibition of
MMP-9/MMP-2 suppressed CCI induced mechanical allodynia and concomitant TNF-a and
IL-17A expression in nerves
Li et al., Int Immunopharmacol 2012
(Arthritis, Rheumatoid) :
In addition, celastrol inhibited
IL-17A induced matrix metalloproteinase (MMP)-9 mRNA and protein expression, and the proteolytic activity of
MMP-9 in RA-FLSs
Li et al., Mol Immunol 2013
(Arthritis, Rheumatoid) :
Moreover,
IL-17A induced expression of MMP2 and
MMP9 under hypoxia was accompanied by increased activation of nuclear factor-?B ( NF-?B ) /hypoxia-inducible factor-1a (HIF-1a)
Wang et al., Cancer Biol Ther 2013
(Bone Neoplasms...) :
We observed that
IL-17A/IL-17RA interaction
promoted the expression of VEGF,
MMP9 and CXCR4 in OS cells, which might partly explain the enhanced metastasis of OS cells
Wu et al., J Endod 2013
:
This study aimed to investigate the
effects of
interleukin (IL)-17 on the mRNA expression and protein production of MMP-1, MMP-2,
MMP-9 , MMP-13, TIMP-1, and EMMPRIN through human periodontal ligament cells ...
IL-17 significantly up-regulated MMP-1 and MMP-13 mRNA expression but
down-regulated MMP-2,
MMP-9 , and TIMP-1 mRNA expression ... Furthermore,
IL-17 ( 50 ng/mL ) increased the secreted protein level of MMP-1 and MMP-13 and conversely
reduced the level of MMP-2,
MMP-9 , and TIMP-1
Hayata et al., PloS one 2013
(Melanoma, Experimental...) :
Inhibition of
IL-17A at tumor sites significantly
suppressed CD31,
MMP9 , and VEGF expression in tumor tissue
Xie et al., PloS one 2013
:
Moreover, in cultured cardiac fibroblasts,
IL-17A induced the expression of ADAMTS-1,
MMP-2 , and collagen subtypes I and III and increased the proliferation of fibroblasts