Gene interactions and pathways from curated databases and text-mining

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CISH — PDGFB

Text-mined interactions from Literome

Usui et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Either S1P stimulation or KLF5 overexpression increased the PDGF-B promoter activity in a cis-element dependent manner
Ling et al., J Cardiovasc Pharmacol 2004 : Cis-THD significantly inhibited platelet derived growth factor (PDGF) BB-induced DNA synthesis ( 10 % at 1 nmol/L, 17 % at 10, 100 nmol/L ; 17beta-estradiol : 27 % inhibition at 1, 10 nmol/L, 33 % at 100 nmol/L )
Yu et al., Cardiovasc Res 2011 (MAP Kinase Signaling System) : In VSMCs, ATRA activates and PDGF-BB represses SM22a expression through KLF4 binding to, or dissociating from, its different cis-elements in an acetylation dependent manner