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APC — IL2

Text-mined interactions from Literome

Sponaas et al., Gene Ther 1999 : APC expressing recombinant Ii HEL stimulate a maximal IL-2 response of HEL-specific T hybridoma cells
Colovai et al., Transplantation 2000 : However, neither proliferation nor protein synthesis was required for the ability of Ts to inhibit Th. Ts drastically reduced the capacity of xenoreactive Th cells to produce interleukin (IL)-2 in response to the specific APC , without affecting their surface expression of IL-2 receptor
Yuzawa et al., Transplantation 2003 (Hypersensitivity, Delayed) : The effects of APC0576 on interleukin-2 production and proliferative responses in human peripheral blood mononuclear cells were studied under various stimuli with in vitro culture assay ... APC0576 effectively suppressed interleukin-2 production and proliferation in activated human peripheral blood mononuclear cells
Gorczynski et al., Immunol Lett 1992 : Hepatic APC isolated from mice receiving antigen via the portal vein were unable to induce IL-2 production from a C3H/HEJ anti-B10.BR cell line in vitro, in contrast to splenic APC derived from the same mice
Zhong et al., Anesthesiology 2004 (Myocardial Infarction...) : APC with sevoflurane attenuated NF-kappaB activation and reduced the expression of tumor necrosis factor alpha, interleukin 1, intercellular adhesion molecule 1, and inducible nitric oxide synthase
Mehrotra et al., Immunology 2004 (Melanoma) : Among the various microenvironmental factors, interleukin-10 (IL-10) exhibits a potent immunosuppressive effect on antigen presenting cells (APC)
Kato et al., Cell Immunol 1992 (Second Messenger Systems) : The SN induced IL-2R and proliferation of TH1 clones stimulated with B cell APC , which could not induce IL-2R in the absence of the SN ... When TH1 clones were stimulated with immobilized anti-CD3 or with fixed B cell APC in the presence of partially purified IL-2RIF , these clones expressed IL-2R and showed IL-2 dependent proliferation, whereas they induced neither IL-2R expression nor proliferation in the absence of IL-2RIF activity
DeSilva et al., J Immunol 1991 : Murine Th1 clones that receive signals through their TCR in the absence of APC derived co-stimulatory signals do not produce IL-2 and instead become anergic, i.e., they are subsequently unable to produce IL-2 in response to Ag and normal APC
Norton et al., J Immunol 1991 : In Th1 clones, TCR occupancy together with a costimulatory signal from APC results in IL-2 production
Khan et al., J Clin Invest 1990 : All three clones produced IFN-gamma and IL-2 in varying amounts upon antigenic stimulation in the presence of irradiated APC
Weston et al., J Immunol 1988 : APC from C57BL6-lpr/lpr mice or C3H-lpr/lpr were unable to induce spontaneous proliferation and IL-2 production
Dubey et al., J Immunol 1995 : However, APC expressing both ICAM-1 and B7-1 were much better stimulators of proliferation and IL-2 secretion at low cell numbers, and were far superior inducers of IL-2 at higher numbers, indicating a synergy between the two pathways
Gahring et al., Cell Immunol 1993 : In both mouse strains the CD4+, CD45RBhi subset of primed lymph node cells produced significant levels of IL-2 in response to HGG and APC , whereas no significant IL-2 or IL-4 production was detectable in HGG stimulated CD45RBlo cells of either strain
Wettstein et al., J Immunol 1995 : Four tested HTT Ags appeared not to be acquired by stimulators as exogenous Ags as BALB.B spleen cells but not a mixture of BALB/c spleen cells and C57BL/6 APC stimulated IL-2 production by the respective Th hybrids
Petro et al., Immunol Invest 1994 (Body Weight...) : However, APC of 4Ca mice did not cause greater IL2 or IL3 production
Sperling et al., J Immunol 1993 : Finally, G8 tg cells produced IL-2 only in the presence of APC costimulation or anti-CD28 antibodies, and the addition of exogenous rIL-2 overcame the need for costimulation
Gilbert et al., J Immunol 1993 : In addition, although both HGG presenting APC and IL-2 stimulate Th1 cell cycle progression into G1a, only HGG presenting APC induced Th1 cell anergy in conjunction with n-butyrate
Piuvezam et al., J Immunol 1993 : T cell lines generated against Tct proliferated in response to parasite lysate only in the presence of autologous APC and produced IL-2 , IL-6, and IFN-gamma but not IL-4 in response to PMA plus ionomycin
Prasad et al., Int Immunol 1995 : Although the co-stimulation blocking reagent CTLA-4-Ig mimicked the effect of gamma-irradiation by preventing IL-2 secretion but not AICD, B7 expression on the APC was not radiosensitive, nor did co-stimulation, provided ` in trans ' with a B7-expressing third-party cell, reconstitute antigen-specific hybridoma IL-2 secretion in response to irradiated APC
Toyooka et al., Int Immunol 1996 : While stimulation in vitro to B6 splenic T cells with bm12 antigen presenting cells (APC) induced IL-2 mRNA expression and IL-2 production, T cells stimulated with bm12 B cells expressed much less IL-2 mRNA and secreted very low but detectable levels of IL-2 ... Moreover, IL-2R expression and proliferation induced by stimulation with bm12 APC was inhibited by CTLA-4-Ig, a soluble recombinant fusion protein capable of blocking the CD28 co-stimulatory signals not only stimulate IL-2 production but also induce IL-2R expression by an IL-2 independent mechanism
Guehler et al., J Exp Med 1996 : In response to APC and exogenous peptide, sorted iIEL subsets from Ag+ mice produced IL-2 and IFN-gamma, and proliferated at greatly reduced levels compared to corresponding subsets from Ag- mice
Dennig et al., Cell Immunol 1996 : In addition, in the presence of normal APC , T cells responding to TSST-1 produced much higher amounts of interleukin-2 than T cells proliferating in the presence of HLA class II-negative APC
Cone et al., Cell Immunol 1996 : Cells precultured with dbcAMP or forskolin for 3 days did not proliferate or produce IL-2 in response to antigen and APC , but did proliferate to antigen and APC in the presence of IL-2
Prasad et al., J Autoimmun 1997 : Furthermore, thymic APC did stimulate IL-2 secretion by a non-self reactive hybridoma