◀ Back to WDR5
KMT2D — WDR5
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
WDR5
—
KMT2D
(direct interaction, unspecified method)
Dharmarajan et al., J Biol Chem 2012*
-
IRef Biogrid Interaction:
WDR5
—
KMT2D
(association, x-ray crystallography)
Zhang et al., Nucleic Acids Res 2012
-
IRef Biogrid Interaction:
WDR5
—
KMT2D
(direct interaction, unspecified method)
Zhang et al., Nucleic Acids Res 2012
-
IRef Biogrid Interaction:
WDR5
—
KMT2D
(physical association, affinity chromatography technology)
Wysocka et al., Cell 2005
-
IRef Biogrid Interaction:
WDR5
—
KMT2D
(physical association, affinity chromatography technology)
Patel et al., Dev Cell 2007
-
IRef Biogrid Interaction:
WDR5
—
KMT2D
(physical association, affinity chromatography technology)
Mo et al., J Biol Chem 2006
-
MIPS CORUM WDR5-ASH2L-RBBP5-MLL2 complex:
WDR5-ASH2L-RBBP5-MLL2 complex complex (ASH2L-KMT2D-RBBP5-WDR5)
Wysocka et al., Cell 2005
-
MIPS CORUM MOF complex:
MOF complex complex (KMT2A-KMT2D-KAT8-RBBP5-RNF2-SETD1A-TAF1-TAF6-TAF9-WDR5)
Dou et al., Cell 2005
-
MIPS CORUM UTX-MLL2/3 complex:
UTX-MLL2/3 complex complex (ASH2L-PROSER1-KMT2D-KMT2C-N4BP2-NCOA6-PAXIP1-RBBP5-PPP6R3-KDM6A-WDR5-ZNF281)
Lee et al., Science 2007
-
IRef Corum Interaction:
Complex of 21 proteins
(association, anti tag coimmunoprecipitation)
Dou et al., Cell 2005
-
IRef Corum Interaction:
Complex of KMT2D-ASH2L-RBBP5-WDR5-ASH2L-RBBP5-WDR5-KMT2D
(association, coimmunoprecipitation)
Wysocka et al., Cell 2005
-
IRef Corum Interaction:
Complex of 13 proteins
(association, anti tag coimmunoprecipitation)
Lee et al., Science 2007
-
IRef Hprd Interaction:
Complex of 26 proteins
(in vivo)
Mo et al., J Biol Chem 2006
-
IRef Hprd Interaction:
Complex of 17 proteins
(in vivo)
Mo et al., J Biol Chem 2006
-
IRef Intact Interaction:
Complex of 12 proteins
(association, anti tag coimmunoprecipitation)
Dou et al., Cell 2005
-
IRef Intact Interaction:
Complex of 31 proteins
(association, anti bait coimmunoprecipitation)
Issaeva et al., Mol Cell Biol 2007
-
IRef Intact Interaction:
Complex of 57 proteins
(colocalization, molecular sieving)
Issaeva et al., Mol Cell Biol 2007
Text-mined interactions from Literome
Zhang et al., Endocrine 2004
(MAP Kinase Signaling System) :
Moreover, inhibition of a specific
mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase ( MEK ) by PD98059
blocked FGF2 regulated
MEPE/OF45 expressions, indicating that this regulation requires the MAPK pathway ... Moreover, inhibition of a specific mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase ( MEK ) by PD98059 blocked
FGF2 regulated
MEPE/OF45 expressions, indicating that this regulation requires the MAPK pathway
Morales et al., Mol Cell Biol 2005
:
We showed previously that
MSL3 is
essential for the activation of
MOF 's nucleosomal histone acetyltransferase activity within an MSL1-MOF complex ... Interaction with
MSL1 mediates the activation of
MOF in vitro and the targeting of MSL3 to the X-chromosomal territory in vivo
Zhou et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2005
(Disease Models, Animal...) :
Cytokines are the direct mediators for multiple organ failure (MOF), and
MOF is
triggered by
TNF-alpha and a cascade of cytokine release, with a prolonged high-expression of IL-6
Houk et al., Nano Lett 2009
:
Importantly, we show conclusively that very rapid
TEM induced
MOF degradation leads to agglomeration and stable, easily imaged particles, explaining prior reports of particles larger than MOF pores
Liu et al., Nucleic Acids Res 2009
:
Over expressing wild-type
MEPE/OF45 , but not the mutant MEPE/OF45 ( depleted the key domain to interact with CHK1 )
increases CHK1 levels in the cells and increases the resistance of the cells to IR or CPT. MEPE/OF45, interacting with CHK1, increases CHK1 half-life and decreases CHK1 degradation through the ubiquitine mediated pathway
Li et al., Mol Cell 2009
:
We further demonstrate that
MOF-MSL1v1 is specifically
required for optimal transcription activation of
p53 target genes both in vitro and in vivo
Raja et al., Mol Cell 2010
:
However, depletion of
MCRS2 affects
MOF recruitment to promoters
Krishnan et al., Proc Natl Acad Sci U S A 2011
(Aging, Premature...) :
Given the reversible nature of epigenetic changes, rescue experiments performed either by
Mof overexpression or by
histone deacetylase inhibition promoted repair protein recruitment to DNA damage sites and substantially ameliorated aging associated phenotypes, both in vitro and in vivo
Zhang et al., Nucleic Acids Res 2012
:
Consistently, enzymatic assays reveal that
WDR5 plays an important role in the optimal stimulation of
MLL2-4 , SET1A and SET1B methyltransferase activity by the RbBP5-ASH2L heterodimer
Li et al., Cell stem cell 2012
:
Mof is also
required for
Wdr5 recruitment and H3K4 methylation at key regulatory loci, highlighting the complexity and interconnectivity of various chromatin regulators in ESCs
Nath et al., Clin Exp Immunol 1984
(Leprosy) :
Non-adherent cell supernatants and
MoF from tuberculoid and healthy individuals
had little effect on
IL-2 production
Shimada et al., Nihon Geka Gakkai Zasshi 1998
(Multiple Organ Failure) :
On the other hand, if the antiinflammatory response is greater than the inflammatory response ( CARS ) a compromised state and refractory infection are seen, followed by progressive, irreversible organ dysfunction ( MODS or
MOF induced by
CARS )