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AGTR1 — CASP4

Text-mined interactions from Literome

Matsumoto et al., Shock 2003 (Necrosis) : DNA fragmentation, Lactate dehydrogenase ( LDH ) release, and caspase-3 activity were measured in cultured HAEC after exposure to hypoxia in the presence or absence of an AT1-RA ( candesartan, CS ) and/or an ACEI ( temocaprilat, TC )
Katunuma et al., FEBS Lett 2006 : Epigallo-catechin-gallate showed the strongest inhibition at 1 x 10 ( -7 ) M to these caspases, but cysteine cathepsins and caspase-8 were not inhibited
Kishi et al., Hypertension 2010 (Disease Models, Animal) : Angiotensin II type 1 receptor activated caspase-3 through ras/mitogen activated protein kinase/extracellular signal regulated kinase in the rostral ventrolateral medulla is involved in sympathoexcitation in stroke-prone spontaneously hypertensive rats ... These findings suggest that in SHRSP, angiotensin II type 1 receptor activated caspase-3 acting through the Ras/p38 MAPK/ERK pathway in the RVLM might be involved in sympathoexcitation, which in turn plays a crucial role in the pathogenesis of hypertension
Fauconnier et al., Proc Natl Acad Sci U S A 2011 (Myocardial Reperfusion Injury...) : At 1 and 15 d after reperfusion, caspase-8 activation resulted in S-nitrosylation of the RyR2 and depletion of calstabin2 from the RyR2 complex, resulting in diastolic sarcoplasmic reticulum ( SR ) Ca ( 2+ ) leak
Chen et al., Chem Res Toxicol 2012 : CA at 1 µM suppressed the 6-OHDA induced nuclear condensation, reactive oxygen species generation, and cleavage of caspase 3 and PARP
Chai et al., Acta Biochim Biophys Sin (Shanghai) 2012 (Pre-Eclampsia) : AT1-AA increased TNF secretion and caspase-3 activities ... AT1 receptor blockade completely abrogated AT1-AA induced TNF-a secretion, caspase-3 activation, and cardiomyocyte apoptosis