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FASLG — FOS

Pathways - manually collected, often from reviews:

• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: NFAT1/JUN/FOS complex (FOS-JUN-NFATC2) → FASLG (FASLG) (transcription, activates) Macián et al., EMBO J 2000, Hodge et al., Immunity 1996*, Latinis et al., J Biol Chem 1997*
  Evidence: mutant phenotype, assay, other species

Text-mined interactions from Literome

Harwood et al., J Biol Chem 2000 (Colonic Neoplasms) : Regulation of FasL by NF-kappaB and AP-1 in Fas dependent thymineless death of human colon carcinoma cells ... These results demonstrate the crucial roles for NF-kappaB and AP-1 in the regulation of FasL in Fas mediated thymineless death of colon carcinoma cells
Siegmund et al., J Biol Chem 2001 : Fas associated death domain protein ( FADD ) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) via a FLICE inhibitory protein (FLIP) regulated pathway
Imamura et al., J Biol Chem 2004 (Inflammation) : Reporter gene assays involving wild-type and mutated IL-8 promoters and NF-kappaB- and AP-1 reporter constructs indicated that an FasL induced NF-kappaB and AP-1 activity are required for maximal promoter activity
Trauzold et al., FASEB J 2005 (Adenocarcinoma...) : Stimulation of TRAF2 overexpressing cells with CD95 ligand led to induction of NF-kappaB and AP-1 , enhanced IL-8- and uPA-secretion, and a further increased invasiveness
Matsumoto et al., FEBS J 2007 (MAP Kinase Signaling System) : Here, we found that a dominant negative mutant of c-Jun, a component of the activator protein-1 (AP-1) transcription factor, inhibits FasL induced AP-1 activity and IL-8 production in HEK293 cells ... The FasL induced AP-1 activation could be inhibited by deleting or introducing the lymphoproliferation ( lpr ) -type point mutation into the Fas death domain ( DD ), knocking down the Fas associated DD protein (FADD), abrogating caspase-8 expression with small interfering RNAs, or using inhibitors for pan-caspase and caspase-8 but not caspase-1 or caspase-3 ... Furthermore, wildtype, but not a catalytically inactive mutant, of caspase-8 reconstituted the FasL induced AP-1 activation in caspase-8-deficient cells ... Unexpectedly, an inhibitor for JNK but not for MAPK/ERK kinase inhibited the FasL induced AP-1 activation and IL-8 production ... These results demonstrate that FasL induced AP-1 activation is required for optimal IL-8 production, and this process is mediated by FADD, caspase-8, and JNK