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MPO — PTGS2

Text-mined interactions from Literome

Tanigawa et al., Am J Physiol Gastrointest Liver Physiol 2004 (Gastritis...) : Inhibition of both COX-1 and -2 by indomethacin or concurrent treatment with SC-560 and NS-398 resulted in a stronger increase in MPO activity and apoptosis than inhibition of either COX-1 or -2 alone
Tewari-Singh et al., PloS one 2012 (Inflammation) : In skin cells, silibinin ( 10 µM ) treatment 30 min after 0.35/0.5 mM CEES exposure caused a significant ( p < 0.05 ) reversal in CEES induced decrease in cell viability, apoptotic and necrotic cell death, DNA damage, and an increase in oxidative stress. Silibinin ( 1 mg ) applied topically to mouse skin 30 min post-CEES exposure ( 2 mg ), was effective in reversing CEES induced increases in skin bi-fold ( 62 % ) and epidermal thickness ( 85 % ), apoptotic cell death ( 70 % ), myeloperoxidase activity ( complete reversal ), induction of iNOS, COX-2 , and MMP-9 protein levels ( > 90 % ), and activation of transcription factors NF-?B and AP-1 ( complete reversal )
Rider et al., Journal of enzyme inhibition 1996 : Comparative effects of selective cyclooxygenase 1 and cyclooxygenase 2 inhibitors on myeloperoxidase and 3 alpha-hydroxysteroid dehydrogenase