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HNRNPH1 — IDO1

Text-mined interactions from Literome

Hwu et al., J Immunol 2000 : These results suggest that activation of DCs induces the production of functional IDO , which causes depletion of tryptophan and subsequent inhibition of T cell proliferation
Orabona et al., Blood 2006 : We examined the gene-expression profiles of murine splenic CD8+ DCs rendered highly tolerogenic by interferon-gamma (IFN-gamma), which activates the enzyme indoleamine 2,3-dioxygenase ( IDO, encoded by Indo ) and thus initiates the immunosuppressive pathway of tryptophan catabolism
Popov et al., J Clin Invest 2006 (Granuloma...) : Induction of IDO by DCs is a cell-autonomous response to Listeria monocytogenes infection and was also observed in other granulomatous infections with intracellular bacteria, such as Bartonella henselae
Zhu et al., Mult Scler 2007 (Multiple Sclerosis...) : The suppression of T-cell proliferation mediated by estrogen exposed DCs was partly abolished by the IDO-inhibitor, 1-methyl-dl-tryptophan, indicating that estrogen exposed DCs induced IDO dependent T-cell suppression
Hill et al., Transplantation 2007 : We show that IDO and NO are responsible for the impaired capacity of DCs from CTLA4Ig treated rats to stimulate allogeneic T cells
Belladonna et al., J Immunol 2008 : CD8 ( - ) DCs do not produce TGF-beta, yet externally added TGF-beta induces IDO and turns those cells from immunogenic into tolerogenic cells
Sun et al., J Immunol 2009 : In this study we report that HDAC inhibition acetylates and activates STAT-3, which regulates DCs by promoting the transcription of IDO
Onodera et al., J Immunol 2009 (Leukopenia) : Together with our previous observation that MLN DCs contain much intracytoplasmic cellular debris in vivo, these results indicate that reciprocal interactions between the DCs and Tregs via both B7/CTLA-4 and CCL22/CCR4 lead to IDO induction in MLN DCs, which may be initiated and/or augmented by the phagocytosis of autologous apoptotic cells by intestinal DCs
Liu et al., Blood 2010 (Neoplasms) : IDO1 induction triggers DC apoptosis, whereas INCB024360 reverses this and increases the number of CD86 ( high ) DCs , potentially representing a novel mechanism by which IDO1 inhibition activates T cells