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IL17D — IL2
Text-mined interactions from Literome
Owaki et al., J Immunol 2006
:
In this study we demonstrate that
IL-27 inhibits CD28 mediated
IL-2 production and that suppressor of cytokine signaling 3 ( SOCS3 ) plays a critical role in the inhibitory effect ... Although IL-27 enhanced IFN-gamma production from naive CD4+ T cells stimulated with plate coated anti-CD3 and anti-CD28 in the presence of IL-12,
IL-27 simultaneously
inhibited CD28 mediated
IL-2 production ... These results suggest that
IL-27 inhibits CD28 mediated
IL-2 production and also IL-2 responses, and that SOCS3, whose expression is induced by IL-27, plays a critical role in the inhibitory effect in a negative feedback mechanism
Shen et al., Scand J Rheumatol 2013
(Behcet Syndrome...) :
Elevated levels of
interleukin-27 and
effect on production of interferon-? and
interleukin-17 in patients with Behçet 's disease