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AHSA1 — TGFB1
Text-mined interactions from Literome
Liao et al., Cell Res 2001
(MAP Kinase Signaling System) :
The data indicate that the activation of
p38 is
involved in
TGF-beta1 mediated gene expression and apoptosis
Sato et al., J Invest Dermatol 2002
(Scleroderma, Systemic) :
Furthermore, a specific inhibitor of
p38 suppressed
transforming growth factor beta stimulation of collagen type I mRNA and the alpha2 ( I ) collagen promoter activity
Frippiat et al., Free Radic Biol Med 2002
:
Here we show that sustained
p38 ( MAPK ) phosphorylation is
responsible for both H2O2 induced overexpression of
TGF-beta 1 and subsequent TGF-beta 1-induced appearance of these biomarkers
Dai et al., Am J Respir Cell Mol Biol 2003
(Fibrosis) :
With diesel exhaust particles, tetramethylthiourea and deferoxamine had no effect, but extracellular signal regulated kinase and
p38 inhibitors completely
blocked effects on procollagen and
TGF-beta 1
Ungefroren et al., J Biol Chem 2005
:
We have recently shown that induction of biglycan (BGN) expression by
transforming growth factor-beta1 ( TGF-beta1 )
required sequential activation of both Smad and
p38 mitogen activated protein kinase signaling ( Ungefroren, H., Lenschow, W., Chen, W.-B., and Kalthoff, H. ( 2003 ) J. Biol. Chem. 278, 11041-11049 )
Guo et al., World J Gastroenterol 2005
:
Since
p38 phosphorylation
induced by
TGF-beta1 plays an important role in caspase activation and apoptosis, TPA and EGF induced p38 phosphorylation may not be requisite for their anti-apoptotic function
Perng et al., Chest 2007
(Asthma...) :
Pretreatment with dexamethasone
inhibited TGF-beta1 production at both messenger RNA and protein levels by inhibiting
p38 MAP kinase phosphorylation
Ding et al., J Biol Chem 2008
(Disease Models, Animal...) :
FRNK overexpression blocks
TGF-beta1 induced ERK or
p38 MAPK activation in the presence, and surprisingly, in the absence of FAK
Zimpelmann et al., American journal of physiology. Renal physiology 2009
(MAP Kinase Signaling System) :
Stimulation of
p38 MAPK phosphorylation by Ang- ( 1-7 )
leads to release of arachidonic acid and production of
TGF-beta1 and extracellular matrix proteins
Houde et al., J Biol Chem 2009
:
We show here that early events consisted of a trend toward increased expression of extracellular signal regulated kinase ( ERK ), and then
TGF-beta1 significantly
induced the activation of
p38 and Smad2 in a time dependent manner
Wei et al., Cell Biol Int 2013
:
Transforming growth factor-beta1 ( TGF-beta1 ) is the key
inducer of EMT and the
p38 mitogen activated protein kinases ( p38 MAPK ), an major intracellular signal transduction pathway is involved in TGF-beta1 induced EMT