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IRF6 — JAK3
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Severgnini et al., Am J Physiol Lung Cell Mol Physiol 2004
(Acute Disease...) :
We also demonstrated that
LPS activates both the STAT kinases, Src and
JAK , in the lung with kinetics that are consistent with STAT activation
Liu et al., Zhonghua Shao Shang Za Zhi 2005
:
In addition, the cells were divided into normal control,
LPS stimulation,
JAK2 inhibition ( with AG490 treatment 2 hours before LPS stimulation ), STAT1 inhibition ( with fludarabine treatment 2 hours before LPS stimulation ) and STAT3 inhibition ( with rapamycin treatment 2 hours before LPS stimulation ) groups
Wu et al., Br J Pharmacol 2009
:
Effects of tripterine were investigated on endothelial barrier function, inducible nitric oxide synthase (iNOS) expression, nicotinamide adenine dinucleotide phasphate ( NADPH ) oxidase activity, 3-nitrotyrosine formation, protein phosphatase type 2A (PP2A) activity,
activation of extracellular regulated kinase (ERK), c-Jun terminal kinase (JNK) and
Janus kinase ( Jak2 ), and degradation of IkappaB in microvascular endothelial cells exposed to pro-inflammatory stimulus [
lipopolysaccharide (LPS) + interferon gamma (IFNgamma) ] and on vascular permeability in air pouches of mice injected with LPS + IFNgamma