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PTH — SMAD3

Text-mined interactions from Literome

Sowa et al., J Biol Chem 2003 : Although our previous study suggested that Smad3 is an important molecule for the stimulation of bone formation, no reports have been available about the effects of PTH on Smad3 ... In this present study, we examined the effects of PTH on Smad3 and the physiological significance in mouse osteoblastic cells ... Protein kinase A (PKA) activator as well as protein kinase C ( PKC ) activators increased Smad3 protein level, and both PKA and PKC inhibitors antagonized PTH induced Smad3 , indicating that PTH promotes the production of Smad3 through both PKA and PKC pathways
Inoue et al., J Cell Biochem 2009 : Transient transfection of Smad3AAVA inhibited the PTH induction of total beta-catenin and reduction of phosphorylated beta-catenin levels at 6 and 24 h, but not at 1 h, indicating that the early effects occur independently of TGF-beta receptor signaling
Yang et al., Ann N Y Acad Sci 2010 (Bone Diseases, Developmental) : This study provides an in vivo tool to study the role of BMPRII in BMP/Smad signaling and the regulation of this pathway by PTH and Wnts