◀ Back to PLD3

PLD3 — PTGS2

Text-mined interactions from Literome

Park et al., Mol Pharmacol 2002 : Regulation of cyclooxygenase-2 expression by phospholipase D in human amnion derived WISH cells ... In addition, evidence that PLD was involved in the stimulation of COX-2 expression was provided by the observations that COX-2 expression was stimulated by the dioctanoyl phosphatidic acid ( PA ) and that the prevention of PA dephosphorylation by 1-propranolol potentiated COX-2 expression by IL-1 beta ... The results of this study indicate that in human amnion cells, IL-1 beta might activate PLD through an upstream protein kinase C to elicit p38 and finally induce COX-2 expression
Grab et al., Biochim Biophys Acta 2004 : Differential role for phospholipase D1 and phospholipase D2 in 12-O-tetradecanoyl-13-phorbol acetate stimulated MAPK activation, Cox-2 and IL-8 expression
Kim et al., J Biol Chem 2004 (Astrocytoma) : Furthermore, evidence that PLD was involved in EGCG induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid ( PA ), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG ... Collectively, our results demonstrate for the first time that PLD isozymes mediate EGCG induced COX-2 expression through PKC and p38 in immortalized astroglial line and normal astrocyte cells
Ahn et al., Biochim Biophys Acta 2007 (Astrocytoma) : In addition, evidence that PLD activity was involved in the stimulation of COX-2 expression was provided by the observations that overexpression of wild type PLD isozymes, but not catalytically inactive PLD isozymes, stimulated CoCl ( 2 ) -induced COX-2 expression and PGE ( 2 ) production