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TP53 — TXN
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ueno et al., J Biol Chem 1999
(Colonic Neoplasms) :
Here, we have investigated the
role of
TRX in the regulation of
p53 activity ... Electrophoretic mobility shift assay showed that
TRX augmented the DNA binding activity of p53 and also further potentiated Ref-1 enhanced
p53 activity ... The p53 dependent p21 transactivation induced by CDDP was inhibited by mTRX overexpression, suggesting that
TRX dependent redox regulation is physiologically
involved in
p53 regulation ... Hence,
TRX dependent redox regulation of
p53 activity indicates coupling of the oxidative stress response and p53 dependent repair mechanism
Matsutani et al., Clin Cancer Res 2001
(Breast Neoplasms) :
We reported previously that
thioredoxin (TRX) regulates the DNA binding activities of ER and
p53 in vitro
Chowdhury et al., J Gen Virol 2003
:
Both HTLV-I Tax and the proteasome-specific inhibitor MG132 inhibited
p53 mediated
TRX protein degradation
Seemann et al., Oncogene 2005
(Breast Neoplasms) :
In yeasts deficient for thioredoxin (Trx) reductase ( TRR ), p53 accumulates in an inactive, oxidized form, suggesting a
role for
TRR-Trx in controlling
p53
Ravi et al., J Biol Chem 2005
:
Additionally
Trx increased
p53-DNA binding and expression in response to anthracyclines
Hadj Amor et al., FEMS Yeast Res 2008
:
Using differential display and Northern blot analysis, we demonstrated that human wt
p53 expression in yeast
leads to gene repression of
thioredoxin ( TRX1/2 ), a highly conserved multifunctional antioxidative and antiapoptotic protein family
Stoner et al., Biochemistry 2009
:
To investigate the
role of
thioredoxin in controlling
p53 activity, the level of reporter gene transactivation by p53 was determined in yeast lacking the TRX1 and TRX2 genes encoding cytosolic thioredoxin ... Subsequent analyses showed that thioredoxin deletion suppressed the inhibitory effect of thioredoxin reductase deletion, suggesting that accumulation of oxidized
thioredoxin in mutant yeast was
necessary for
p53 inhibition