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GPX2 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GPX2 — TP53 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Intact Interaction: GPX2 — TP53 (physical association, two hybrid) Wang et al., Molecular systems biology 2011

Text-mined interactions from Literome

Tan et al., J Biol Chem 1999 : Transcriptional activation of the human glutathione peroxidase promoter by p53 ... In a search for a cis-element that confers potential p53 regulation of GPX , we identified a p53 binding site in the promoter of the GPX gene ... The p53 binding and transactivation of the GPX promoter were enhanced by etoposide in p53 positive U2-OS cells ... Etoposide induced transactivation was blocked by a dominant negative p53 mutant, indicating that endogenous wild type p53 , upon activation by etoposide, transactivated the GPX promoter
Hussain et al., Cancer Res 2004 : p53 induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis ... These results identify a novel mechanism of p53 dependent apoptosis in which p53 mediated up-regulation of MnSOD and GPx , but not CAT, produces an imbalance in antioxidant enzymes and oxidative stress
Yan et al., J Biol Chem 2006 : Here, we found that GPX2 , which encodes a glutathione peroxidase, is up-regulated by p63 but not p53 ... Interestingly, the protective function of GPX2 is p53 dependent