◀ Back to INS

INS — RPS6KB1

Text-mined interactions from Literome

Patel et al., J Biol Chem 2002 : Rapamycin inhibited the mammalian target of rapamycin (mTOR) and the subsequent activation of p70/p85 S6 protein kinase-1 (S6K1) by insulin , whereas amino acid depletion prevented insulin induction of these signaling molecules
Shah et al., Biochem J 2002 : In the present study, we have shown that 4-amino-5- ( 4-methylphenyl ) -7- ( t-butyl ) pyrazolo [ 3,4-d ] pyrimidine ( PP1 ), a selective inhibitor of the Src family of non-receptor tyrosine kinases, interferes with the activation of 70 and 85 kDa S6K gene products ( p70S6K1 and p85S6K1 ) by insulin , insulin-like growth factor 1, sodium orthovanadate and activated alleles of phosphoinositide 3-kinase and H-Ras
Anand et al., Am J Physiol Endocrinol Metab 2002 : Initial studies demonstrated markedly decreased insulin mediated activation of ribosomal protein S6 kinase 1 ( S6K1 ) in the fetus
Bigot et al., J Nutr 2003 : Refeeding and insulin regulate S6K1 activity in chicken skeletal muscles
Beugnet et al., Biochem J 2003 : We show in the present study that inhibition of protein synthesis by any of several protein synthesis inhibitors tested allows insulin to regulate 4E-BP1 or S6K1 in amino-acid deprived cells, as does the addition of amino acids to the medium ... In particular, insulin activates S6K1 and promotes initiation factor complex assembly in amino-acid deprived cells treated with protein synthesis inhibitors, but can not do so in the absence of these compounds
Suh et al., J Biol Chem 2003 : The stimulating type TSHR antibodies from patients with Graves disease also induced S6K1 activation, whereas the blocking type TSHR antibodies from patients with primary myxedema inhibited TSH- but not the insulin induced phosphorylation of S6K1
Krymskaya et al., Cell Signal 2003 : Growth factors and insulin promote Akt/PKB dependent phosphorylation of tuberin, which in turn, releases S6K1 from negative regulation by tuberin and results in the activation of S6K1
Bigot et al., Br J Nutr 2003 (Starvation) : S6K1 activity was correlated with plasma insulin level, suggesting a probable insulin dependent S6K1 activation
Tremblay et al., Endocrinology 2005 : Activation of mTOR/S6K1 by insulin was associated with a rapamycin-sensitive increase in Ser636/639 phosphorylation of insulin receptor substrate (IRS)-1 but, surprisingly, did not result in impaired IRS-1 associated phosphatidylinositol (PI) 3-kinase activity ... Insulin also activated S6K1 and increased phosphorylation of IRS-1 on Ser636/639 in human adipocytes
Khamzina et al., Endocrinology 2005 (Disease Models, Animal...) : Time-course studies also revealed that mTOR and S6K1 activation by insulin was accelerated in tissues of obese rats, in association with increased inhibitory phosphorylation of insulin receptor substrate-1 (IRS-1) on Ser636/Ser639 and impaired Akt activation ... Insulin caused a time dependent activation of mTOR and S6K1 in HepG2 cells
Williamson et al., Am J Physiol Endocrinol Metab 2005 : INS also promoted phosphorylation of ERK1/2, S6K1 , and 4E-BP1 and dephosphorylation of eIF4E
Kwintkiewicz et al., Biol Reprod 2006 : Phosphorylation of AKT was stimulated by insulin only, while phosphorylation of MAPK3/1 and RPS6KB1 was increased by insulin and oxidative stress ... Insulin induced and oxidative stress induced phosphorylation of RPS6KB1 was partly inhibited by wortmannin and partly by PD98059 ; the greatest inhibition was observed in the presence of a combination of wortmannin plus PD98059 ... Effects of insulin and oxidative stress on phosphorylation of RPS6KB1 were confirmed by kinase activity assays
Zhou et al., Carcinogenesis 2007 (Neovascularization, Pathologic...) : In this study, we demonstrated that insulin induced H2O2 production and p70S6K1 activation in PC-3 prostate cancer cells ... The inhibition of H2O2 production by catalase abolished insulin induced p70S6K1 activation ... These results suggest that insulin induced HIF-1alpha and VEGF expression through H2O2 production and p70S6K1 activation in prostate cancer cells
Matsushima et al., J Biol Chem 2006 : In cultured cells, overexpression of TRB3 completely inhibited insulin stimulated S6K1 activation by mammalian target of rapamycin, whereas knockdown of endogenous TRB3 increased both basal and insulin stimulated activity ... In C57BL/6 mice, adenoviral overexpression of TRB3 inhibited insulin stimulated activation of hepatic S6K1 ... Both insulin and feeding activate S6K1 in db/db mice, but only insulin activates in the C57BL/6 strain
Duchêne et al., Domest Anim Endocrinol 2008 (Liver Neoplasms, Experimental...) : Involvement of the ERK1/2 MAPK pathway in insulin induced S6K1 activation in avian cells ... In mammals, insulin regulates S6K1 , a key enzyme involved in the control of protein synthesis, via the well documented phosphoinositide-3'kinase (PI3K) pathway ... Conversely, S6K1 is activated by insulin in avian muscle despite the relative insulin insensitivity of the PI3K pathway in this tissue ... Insulin stimulation led to ERK2 and S6K1 phosphorylation, and concomitantly increased kinase activity ... U0126, an inhibitor of the ERK MAPK pathway, completely abolished insulin induced S6K1 phosphorylation and activity in chicken myoblasts, whereas its effect was only partial in LMH cells
Hou et al., J Biol Chem 2007 : Mutation of Ser-411 to Ala ablated insulin induced Thr-389 phosphorylation and S6K1 activation, whereas mutation mimicking Ser-411 phosphorylation did not show any effect
Sancak et al., Mol Cell 2007 : Insulin stimulates the phosphorylation of S6K1 , an mTORC1 substrate, but it is not known how mTORC1 kinase activity is regulated
Moschella et al., J Mol Cell Cardiol 2007 : Expression of DN-PKC ( epsilon ) blocked ET-1 stimulated mTOR S2448 and S6K1 S421/T424 and T389 phosphorylation but had no effect on insulin stimulated S6K1 phosphorylation ... These data indicate that : ( i ) PKC ( epsilon ) is required for ET-1 stimulated T421/S424 phosphorylation of S6K1, ( ii ) both PKC ( epsilon ) and PKC ( delta ) are required for ET-1 stimulated mTOR S2448 and S6K1 T389 phosphorylation, ( iii ) PKC ( delta ) is also required for insulin stimulated mTOR S2448 and S6K1 T389 phosphorylation
Kim et al., J Biol Chem 2008 (Carcinoma, Hepatocellular...) : IL-6 activates S6K1 in these cells, but unexpectedly, S6K1 is not involved in IL-6 inhibition of insulin signaling, since the effect of IL-6 persists in cells with drastically reduced S6K1 levels induced by RNA interference, suggesting that the function of mTOR signaling is through a mechanism different from the prevailing model of S6K1 phosphorylation of insulin receptor substrate-1
Deshmukh et al., Mol Endocrinol 2008 : Insulin stimulation increased phosphorylation of S6K1 ( Thr389 ), ribosomal protein S6 ( Ser235/236 ), and 4E-BP1 ( Thr37/46 ) ( P < 0.01 ) in WT, AMPK alpha2 KO, and AMPK gamma3 KO mice
Wang et al., Cell Microbiol 2009 : Infected cells still phosphorylated S6K1 and 4E-BP1 in response to insulin , although the S6K1 response was blunted
Rivas et al., J Endocrinol 2009 : Palmitate exposure ( 4 h ) increased insulin stimulated S6K1 Thr389 phosphorylation by 60 %, indicating activation of mTORC1
Blancquaert et al., Mol Endocrinol 2010 : mTORC1 dependent S6K1 phosphorylation in response to both insulin and cAMP required amino acids, whereas inhibition of AMP activated protein kinase and glycogen synthase kinase 3 enhanced insulin but not cAMP effects
Deldicque et al., PloS one 2011 : In spite of the decrease in basal PKB phosphorylation, insulin ( 10-50 nM ) could still activate both PKB and S6K1
Will et al., Fertil Steril 2012 (MAP Kinase Signaling System) : Treatment with metformin inhibited insulin induced activation of Erk1/2 and S6K1
Palaniappan et al., Mol Cell Endocrinol 2013 : Inhibition of ERK1/2 signaling caused partial reduction of insulin induced phosphorylation of RPS6KB1 and RPS6 whereas inhibition of PI3-kinase signaling completely blocked the insulin response