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INS — PLD1

Text-mined interactions from Literome

Emoto et al., J Biol Chem 2000 : Insulin stimulated PLD activity in cells expressing high levels of insulin receptors but no such insulin effect was detected in 3T3-L1 adipocytes
Chen et al., Endocrinology 2000 : The early induction of PLD1 probably contributes to the early stimulatory effects of IL-1beta on islet insulin release
Slaaby et al., Biochem J 2000 : Insulin induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade
Bowen et al., Metabolism 2001 (Insulinoma...) : Glucose and insulin regulate glycosylphosphatidylinositol-specific phospholipase D expression in islet beta cells
Schofield et al., Mol Genet Metab 2002 (Diabetes Mellitus, Experimental...) : Insulin reduces serum glycosylphosphatidylinositol phospholipase D levels in human type I diabetic patients and streptozotocin diabetic rats
Li et al., BMC cell biology 2003 : Here we tested the hypothesis that ARF-guanine nucleotide exchange factors ( ARF-GEFs ) of the cytohesin/ARNO family mediate the activation of ARF and PLD by insulin ... Overexpression of wild type ARNO significantly increased insulin stimulated PLD activity, and mutations in the Sec7 and PH domains, or deletion of the PH or CC domains inhibited the effects of insulin
Hughes et al., J Biol Chem 2004 : Phospholipase D1 regulates secretagogue stimulated insulin release in pancreatic beta-cells
Huang et al., Mol Biol Cell 2005 : PLD1 is found on Glut4 containing vesicles, is activated by insulin signaling, and traffics with Glut4 to exocytic sites
Salvador et al., J Neurosci Res 2005 : In adult animals, in the presence of the tyrosine phosphatase inhibitor ( sodium o-vanadate ), insulin stimulated PLD activity at 5 min incubation
Andersson et al., Mol Cell Endocrinol 2005 : In iNOS-/- islets, IL-1beta at high glucose induced a delayed and prolonged stimulation of insulin secretion, and this was followed by an increase in phospholipase D mRNA expression
McHarg et al., Endothelium : journal of endothelial cell research 2008 : This study compares activation of the key enzyme phospholipase D ( PLD ) by the vasoconstrictors angiotensin II ( AII ) and lysophosphatidylcholine ( lysoPC ), and the vasodilator insulin , in primary human microvascular endothelial cells ( HMVECs ) and human umbilical vein endothelial cells ( HUVECs ) ... Insulin significantly increased PLD activity in both cell types with maximum activation at 1 nmol/L ... Again differential sensitivity was observed ; 10 nmol/L insulin significantly stimulated PLD in HUVECs but not HMVECs
Ma et al., Exp Mol Med 2010 : Role of phospholipase D1 in glucose induced insulin secretion in pancreatic Beta cells ... As glucose is known to induce insulin secretion in pancreatic Beta cells, this study investigated the role of a phospholipase D ( PLD ) -related signaling pathway in insulin secretion caused by high glucose in the pancreatic Beta-cell line MIN6N8 ... The dominant negative PLD1 inhibited glucose induced Beta2 expression, and glucose induced insulin secretion was blocked by treatment with 1-butanol or PLD1-siRNA
Metz et al., Biochem J 1990 : Stimulation of insulin release by phospholipase D ... Chromatographically purified PLD from Streptomyces chromofuscus stimulated the accumulation of PA in [ 14C ] arachidonate- or [ 14C ] myristate prelabelled islets, and also promoted insulin secretion over an identical concentration range ... PLD induced insulin release did not appear to require influx of extracellular Ca2+, nor could the activation of protein kinase C clearly be implicated
Cassese et al., PloS one 2013 (Insulin Resistance...) : In skeletal muscle of these mice, D4 over-expression inhibited PED/PEA-15-PLD1 interaction, decreased Protein Kinase C alpha activation and restored insulin induced Protein Kinase C zeta activation, leading to amelioration of insulin dependent glucose uptake
Kiechle et al., Ann Clin Lab Sci 1995 : These results suggest that adenosine receptor occupancy inhibits phospholipid methylation, is required for insulin stimulation of phospholipid methylation, and may perhaps activate a phosphatidylcholine-specific phospholipase C or phospholipase D
Gómez-Muñoz et al., J Biol Chem 1995 : C2- and C6-ceramides blocked the activation of phospholipase D by sphingosine 1-phosphate, and this inhibition was not affected by insulin
Li et al., Microvasc Res 1995 : Insulin potentiated both PLD- and PDGF induced DNA synthesis
Rydzewska et al., Pancreas 1995 : Activation of pancreatic acinar cell phospholipase D by epidermal, insulin-like , and basic fibroblast growth factors involves tyrosine kinase
Donchenko et al., Biochim Biophys Acta 1994 : Insulin initially stimulated phosphatidylcholine dependent phospholipase D ( PC-PLD ) with a significant increase in both PA and intracellular as well as extracellular choline ... Experiments performed in the presence of 1 microM phorbol 12-myristate 13-acetate ( PMA ) indicated that protein kinase C ( PKC ) mediated the insulin effect on PC-PLC, but not on PC-PLD
Knoepp et al., J Biol Chem 1996 : Insulin did not enhance activation of phospholipase D in response to phorbol ester
Standaert et al., Biochem J 1996 (Diabetes Mellitus, Type 2) : Insulin rapidly activated a phospholipase D that hydrolyses phosphatidylcholine ( PC ), and this activation was accompanied by increases in diacylglycerol and translocative activation of PKC-alpha and PKC-beta in the plasma membrane
Standaert et al., Endocrinology 1996 : Our findings provide the first evidence that insulin stimulates Rho translocation and activates PC-PLD in L6 skeletal muscle cells
Karnam et al., J Biol Chem 1997 : C3 transferase, which inhibits and depletes Rho, inhibited PC-PLD activation by insulin in intact adipocytes
Shome et al., Curr Biol 1997 : ARF proteins mediate insulin dependent activation of phospholipase D ... We have tested the hypothesis that ARF proteins are involved specifically in insulin induced activation of PLD ... Insulin activated PLD in permeabilized HIRcB cells by a process that required GTPgammaS and ARF ... The activation of ARF proteins is stimulated by insulin and this process plays an important role in insulin mediated regulation of PLD