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GPR39 — INS

Text-mined interactions from Literome

Dalle et al., Mol Cell Biol 2002 (MAP Kinase Signaling System) : Insulin induces heterologous desensitization of G-protein coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1
Bavirti et al., Metabolism 2003 (Diabetes Mellitus, Type 2...) : The steeper decrease in GPR may have been due to a greater insulin response to oral glyburide in those with IFG
Tremblay et al., Endocrinology 2009 (Disease Models, Animal...) : Disruption of G protein coupled receptor 39 impairs insulin secretion in vivo ... Pancreas morphology and glucose stimulated insulin secretion in isolated islets from wild-type and GPR39 ( -/- ) mice were comparable, suggesting that GPR39 is not required for pancreas development or ex vivo insulin secretion ... Taken together, our data indicate that GPR39 is required for the increased insulin secretion in vivo under conditions of increased demand, i.e. on development of age dependent and diet induced insulin resistance
Lan et al., Br J Pharmacol 2012 : However, in Min6 cells, GPR119 mediated insulin secretion was glucose dependent
Schwetz et al., Am J Physiol Endocrinol Metab 2013 (Calcium Signaling) : Pancreatic ß-cells regulate glucose homeostasis by secreting insulin in response to glucose elevation and G protein coupled receptor ( GPCR ) activation
Matsuda-Nagasumi et al., Diabetes Obes Metab 2013 (Diabetes Mellitus, Experimental...) : G protein coupled receptor/free fatty acid receptor 1 ( GPR40/FFAR1 ) regulates free fatty acid induced insulin secretion