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EPHB2 — MAP3K1
Text-mined interactions from Literome
Rangaswami et al., J Biol Chem 2005
(Neoplasm Invasiveness) :
Sustained activation of JNK1 by overexpression of wild type but not kinase negative
MEKK1 resulted in suppression of
ERK1/2 activation
Enzler et al., J Immunol 2009
:
After TCR costimulation,
MEKK1 predominantly
induces JNK1 activation, whereas the related kinase MEKK2 regulates
ERK5 activation
Hebron et al., Br J Haematol 2013
(Multiple Myeloma...) :
In myeloma tumour cells,
MAP3K8 acts as mitogen induced MAP3K in mitosis and is
required for TNFa mediated
ERK activation
Xu et al., Proc Natl Acad Sci U S A 1995
:
Neither cotransfected nor endogenous
ERK2 is highly
activated by
MEKK1 compared to its stimulation by epidermal growth factor in spite of significant activation of endogenous MEK
Fanger et al., EMBO J 1997
:
Kinase-inactive
MEKK1 , but not MEKK2, 3 or 4, strongly
inhibited EGF stimulated
ERK activity