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ETS1 — PF4

Text-mined interactions from Literome

Okada et al., Blood 2003 : We previously reported that GATA-1 and ETS-1 regulate the rat PF4 promoter and transactivate the PF4 gene ... In nonmegakaryocytic HepG2 cells, GATA-1 and ETS-1 activate the PF4 promoter approximately 10-fold
Minami et al., Eur J Biochem 1998 : Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression ... In order to investigate how the Ets and GATA motifs affect PF4 promoter activity, we constructed Ets and/or GATA motif mutant genes ... A single disruption of either -75Ets , -135GATA, or -30GATA significantly reduced PF4 promoter activity, and double disruptions involving these motifs completely abolished it ... Co-transfection experiments showed that the overexpression of Ets-1 and/or GATA-1 enhanced the expression of the PF4 promoter reporter gene ... These effects of Ets-1 and GATA-1 on PF4 promoter activity are additive ... All these results strongly suggest that both Ets-1 and GATA-1 play key roles in the positive regulation of PF4 gene expression