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MDM2 — SYT1

Text-mined interactions from Literome

Gu et al., Blood 2002 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : MDM2 induces NF-kappaB/p65 expression transcriptionally through Sp1 binding sites : a novel, p53 independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia ... In the presence of wild-type ( wt ) p53, MDM2 increased p65 promoter activity by reversing p53 mediated suppression of p65
Cheney et al., Cancer Biol Ther 2008 (Rhabdomyosarcoma) : Expression of MDM2 in RD cells transcriptionally repressed p65RelA and suppressed NFkappaB activity, resulting in a reduced growth rate and enhanced apoptosis