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PLD1 — PXN
Text-mined interactions from Literome
Bae et al., Exp Mol Med 2001
:
In this study, we investigated the
role of
PLD on the ATP induced Fak activation and
paxillin phosphorylation using two established cell lines : wild type PLD2- and lipase-inactive mutant PLD2-inducible PC12 cells
Pribic et al., Cell Signal 2012
:
Paxillin phosphorylation and complexing with Erk and FAK are
regulated by
PLD activity in MDA-MB-231 cells ... We investigated the
role of
PLD activity on
paxillin regulation, Erk activation and formation of a paxillin-Erk and paxillin-FAK association ... Inhibition of
PLD activity led to an increase in paxillin tyrosine phosphorylation, a decrease in Erk activation, as measured by phosphorylation, and
enhanced association of
paxillin with Erk ... Taken together, these results suggest that Erk activity is governed by
PLD activity and
regulates the tyrosine phosphorylation of
paxillin , potentially explaining its role in cell motility