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SPHK1 — SRC

Text-mined interactions from Literome

Maupas-Schwalm et al., FASEB J 2004 (MAP Kinase Signaling System) : The tPA induced sphingosine kinase-1 activation was mediated by Src , since it was inhibited by herbimycin A and in SrcK- cells ( overexpressing a dominant negative kinase defective form of Src ) and by ERK1/2 ( early phase peaking at 15 min )
Paugh et al., FASEB J 2008 (Glioblastoma) : Similarly, inhibition of c-Src activity by PP2 blocked both EGF induced translocation of SphK1 and PKCdelta to the plasma membrane and up-regulation of PAI-1 expression