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ESR1 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ESR1 → TNF (decreases) Bhat-Nakshatri et al., Br J Cancer 2004*
  Evidence: Using these cells as well as ERalpha-positive MCF-7 and ZR-75-1 cells, we show that tumour necrosis factor alpha (TNFalpha) and the phosphatidylinositol-3-kinase (PI3-kinase) modulate transrepression function of ERalpha by reducing its stability.
• OpenBEL Selventa BEL large corpus: ESR1 → TNF (decreases, TNF Activity) Bhat-Nakshatri et al., Br J Cancer 2004*
  Evidence: Using these cells as well as ERalpha-positive MCF-7 and ZR-75-1 cells, we show that tumour necrosis factor alpha (TNFalpha) and the phosphatidylinositol-3-kinase (PI3-kinase) modulate transrepression function of ERalpha by reducing its stability.

Text-mined interactions from Literome

Bhat-Nakshatri et al., Br J Cancer 2004 (Breast Neoplasms...) : From these results, we propose that TNFalpha expression or PI3-kinase activation lead to reduced levels of ERalpha protein in cancer cells and corresponding loss of transrepression function and acquisition of an invasive phenotype
Lambert et al., J Leukoc Biol 2004 : Estrogen receptor-alpha deficiency promotes increased TNF-alpha secretion and bacterial killing by murine macrophages in response to microbial stimuli in vitro
Kamali-Sarvestani et al., Pathol Oncol Res 2005 (Breast Neoplasms...) : The effect of TNF-alpha on down-regulation of estrogen receptor and blocking the proliferative response of breast cancer cells to estradiol have been demonstrated
Shibaya et al., J Reprod Dev 2007 : These data indicate that PGF2alpha, TNFalpha and IFNgamma regulate ERalpha and ERbeta mRNA expressions in bovine luteal cells