Gene interactions and pathways from curated databases and text-mining

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GNRH2 — LEP

Text-mined interactions from Literome

Parent et al., Regul Pept 2000 : Leptin effects on pulsatile gonadotropin releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine regulated transcript peptide and neuropeptide Y
Woller et al., Experimental biology and medicine (Maywood, N.J.) 2001 : Leptin stimulates gonadotropin releasing hormone release from cultured intact hemihypothalami and enzymatically dispersed neurons
Islami et al., Eur J Obstet Gynecol Reprod Biol 2003 : Leptin secretion, as measured at 4 h, was significantly stimulated by GnRH-II
Seth et al., Endocrinology 2004 : Galanin-like peptide stimulates the release of gonadotropin releasing hormone in vitro and may mediate the effects of leptin on the hypothalamo-pituitary-gonadal axis
Amstalden et al., Anim Reprod Sci 2005 : Effects of leptin on gonadotropin releasing hormone release from hypothalamic-infundibular explants and gonadotropin release from adenohypophyseal primary cell cultures : further evidence that fully nourished cattle are resistant to leptin
Hong et al., Menopause 2007 (Metabolic Syndrome X...) : Leptin might stimulate the increase of plasma gonadotropin releasing hormone levels, which could result in a positive correlation with estrogen in premenopausal women but not in postmenopausal women
Peters et al., Neuroendocrinology 2009 : Effects of galanin and leptin on gonadotropin releasing hormone stimulated luteinizing hormone release from the pituitary