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PIK3CA — PTGS2

Text-mined interactions from Literome

Sheng et al., Cancer Res 2001 (MAP Kinase Signaling System) : Inhibition of MAPK/ERK kinase activity by PD 98059 completely blocked the K-Ras mediated induction of COX-2, whereas inhibition of PI3K/Akt/PKB activity with LY 294002 or by expressing a dominant negative Akt ( Akt-K179M ) partially blocked the induction of COX-2 by K-Ras
St-Germain et al., Molecular cancer 2004 (Endometrial Neoplasms) : Inhibition of PI 3-K with Wortmannin and LY294002 blocked IkappaB phosphorylation, reduced NF-kappaB nuclear activity, reduced COX-2 expression and induced apoptosis
Jang et al., Biochem Biophys Res Commun 2004 : Moreover, inhibition of PI3K by LY294002 caused partial decrease of catalase induced COX-2 transcription and steady-state COX-2 transcript levels, but not COX-2 mRNA stability
St-Germain et al., Int J Oncol 2004 (Endometrial Neoplasms) : Inhibition of PI 3-K with Wortmannin and LY294002 blocked Akt phosphorylation and inhibited expression of COX-2 in mutated-PTEN cells
Chang et al., Mol Pharmacol 2004 : In this study, we explore the role of Ras, phosphoinositide-3-OH-kinase (PI3K) , Akt, and transcription factor nuclear factor-kappaB (NF-kappaB) in YC-1 induced COX-2 expression in A549 cells ... A Ras inhibitor ( manumycin A ), a PI3K inhibitor ( wortmannin ), an Akt inhibitor ( 1l-6-Hydroxymethyl-chiro-inositol2- [ ( R ) -2-O-methyl-3-O-octadecylcarbonate ] ), and an NF-kappaB inhibitor [ pyrrolidine dithiocarbamate ( PDTC ) ] all reduced YC-1 induced COX-2 expression ... Taken together, these results indicate that YC-1 might activate the sGC/cGMP/PKG pathway to induce Ras and PI3K/Akt activation, which in turn initiates IKKalpha/beta and NF-kappaB activation and finally induces COX-2 expression in A549 cells
Chen et al., Mol Biol Cell 2005 : MG132 induced DNA binding activity of C/EBPdelta, but not C/EBPbeta was regulated by p38, PI3K , Src, and protein kinase C. Small interfering RNA of C/EBPdelta suppressed COX-2 expression, further strengthening the role of C/EBPdelta in COX-2 gene transcription
Callegari et al., Int J Mol Med 2006 : The incubation with specific inhibitors of intracellular kinases showed that PI3K is mainly involved in the Ox-HDL3 dependent Cox-2 induction
Pan et al., Biochem Pharmacol 2006 (Cocarcinogenesis...) : Taken together, these results show that acacetin down regulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NF kappa B by interfering with the activation PI3K/Akt/IKK and MAPK, suggesting that acacetin is a functionally novel agent capable of preventing inflammation associated tumorigenesis
Hwang et al., Carcinogenesis 2007 : Taken together, 9Z,11E-CLA inhibits NF-kappaB driven-COX-2 expression by blocking the IKK and PI3K-Akt signaling in TPA treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects
Cao et al., Cell Signal 2007 (MAP Kinase Signaling System...) : We found that PI3K inhibitor wortmannin or LY294002 blocked COX-2 expression induced by IGF-I
Song et al., Gut 2007 (Adenocarcinoma...) : Unconjugated bile acids induce CREB and AP-1 dependent COX-2 expression in Barrett 's oesophagus and OA through ROS mediated activation of PI3K/AKT and ERK1/2
Pan et al., J Agric Food Chem 2008 : Taken together, these results show that pterostilbene down regulates inflammatory iNOS and COX-2 gene expression in macrophages by inhibiting the activation of NFkappaB by interfering with the activation of PI3K/Akt/IKK and MAPK
Sun et al., Toxicol Appl Pharmacol 2008 : These data suggest a possible role of calcium instead of PI3K in CT-induced COX-2 expression in cardiomyocytes
Chen et al., Mol Immunol 2009 : PGN induced COX-2 expression was attenuated by a Rac1 dominant negative mutant ( RacN17 ), PI3K inhibitors ( wortmannin and LY 294002 ), and an Akt inhibitor ( 1L-6-hydroxymethyl-chiro-inositol2- [ ( R ) -2-O-methyl-3-O-octadecylcarbonate ] )
Gao et al., Cancer Sci 2009 (Endometrial Neoplasms) : Leptin induced functional activation of COX-2 is JAK2/STAT3-, MAPK/ERK-, and PI3K/AKT dependent , indicating that COX-2 may be a critical factor of endometrial carcinogenesis in obesity
Bansal et al., PloS one 2009 : PIM2 Induced COX-2 and MMP-9 expression in macrophages requires PI3K and Notch1 signaling
Liao et al., Toxicol Lett 2009 : Cholesterol-3-beta, 5-alpha, 6-beta-triol induced PI(3)K-Akt-eNOS dependent cyclooxygenase-2 expression in endothelial cells
Uddin et al., Int J Cancer 2010 (Ovarian Neoplasms) : Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer
Anggakusuma et al., J Dermatol Sci 2010 (Inflammation) : These results suggest that macelignan protects skin keratinocytes from UVB induced damage and inhibits MMP-9 and COX-2 expression by attenuating the activation of MAPKs and PI3K/Akt
de Oliveira et al., Journal of neuroinflammation 2012 : Interestingly, NVP-BEZ235, a dual PI3K/mTOR inhibitor, enhanced COX-2 and reduced mPGES-1 immunoreactivity, albeit PGE2 and PGD2 levels were enhanced in LPS stimulated microglia ... Taken together, we demonstrate that blockade of mTOR and/or PI3K/Akt enhances prostanoid production and that PI3K/Akt , GSK-3 and mTOR differently regulate the expression of mPGES-1 and COX-2 in activated primary microglia
Xu et al., Cancer Lett 2013 (Stomach Neoplasms) : G17 increased COX-2 expression and cell proliferation were effectively blocked by CCK2R antagonist and inhibitors of JAK2 and PI3K
Díaz-Muñoz et al., J Immunol 2013 : Cyclooxygenase-2 deficiency in macrophages leads to defective p110? PI3K signaling and impairs cell adhesion and migration