Gene interactions and pathways from curated databases and text-mining

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CTNNB1 — E2F1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Li et al., Oncogene 2007 (Colonic Neoplasms) : As expected, beta-catenin induced its downstream target c-Myc, as well as E2F1 and Bcl-2, and this was blocked by siRNA to c-Myc or E2F1
Abramova et al., Biochem Biophys Res Commun 2010 : Here we show that e2f1 expression is regulated through the Wnt/Tcf-pathway : e2f1 promoter activity is inhibited by sodium butyrate ( NaB ) and by overexpression of beta-catenin/Tcf
Xie et al., J Cell Mol Med 2009 : E2F1 represses beta-catenin/TCF activity by direct up-regulation of Siah1 ... Moreover, repression of beta-catenin/TCF activity by E2F1 can be attenuated by shRNA based repression of endogenous Siah1, implying that Siah1 is a bona fide E2F1 target gene, which at least partly, mediates the suppression of beta-catenin/TCF signalling pathway