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IGF2 — PTPN11

Text-mined interactions from Literome

Mañes et al., Mol Cell Biol 1999 (Neoplasm Invasiveness) : On the other hand, IGF-I promotes the association of insulin receptor substrate 1 with the focal adhesion kinase ( FAK ), paxillin, and the tyrosine phosphatase SHP-2 , resulting in FAK and paxillin dephosphorylation
Kwon et al., Endocrinology 2006 : Similarly in cells expressing native SHP-2, IGF-I induced SHP-2 binding to p85, whereas in cells expressing SHP-2/C459S, there was no increase
Shen et al., Cell Mol Life Sci 2010 (MAP Kinase Signaling System) : In vascular smooth muscle cells, IGF-I stimulates SHPS-1/SHP2/Src complex formation which is required for IGF-I stimulated cell proliferation