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TNF — TNFSF4

Text-mined interactions from Literome

Grosenbach et al., Cell Immunol 2003 : These studies demonstrate that ( a) OX40L plays a role in sustaining the long-term proliferation of CD8 ( + ) T cells in addition to the known effect on CD4 ( + ) T cells following activation, ( b ) OX40L enhances the production of Th1 cytokines ( IL-2, IFN-gamma, and TNF-alpha ) from both CD4 ( + ) and CD8 ( + ) while no change in IL-4 expression was observed, and ( c ) the anti-apoptotic effect of OX40L on T cells is likely the result of sustained expression of anti-apoptotic genes while genes involved in apoptosis are inhibited
Burgess et al., J Allergy Clin Immunol 2005 (Asthma) : TNF-alpha increased expression of both CD40 and OX40 ligand on both asthmatic and nonasthmatic airway smooth muscle cells ... IL-1beta alone had no effect, but it attenuated the TNF induced expression of both CD40 and OX40 ligand
Ito et al., J Exp Med 2005 : We further revealed the following three novel functional properties of OX40L : ( a) OX40L selectively promoted TNF-alpha , but inhibited IL-10 production in developing Th2 cells ; ( b ) OX40L lost the ability to polarize Th2 cells in the presence of IL-12 ; and ( c) OX40L exacerbated IL-12 induced Th1 cell inflammation by promoting TNF-alpha, while inhibiting IL-10
Krimmer et al., Allergy 2009 (Asthma) : The aim of this study was to examine the effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on ASM CD40 and OX40L expression ... In contrast, IFN-gamma reduced TNF-alpha induced OX40L expression to a similar extent in both cell types