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BTK — TNF
Text-mined interactions from Literome
Defazio et al., Brain Res 2000
(Multiple Sclerosis) :
These findings indicate that
a TK- rather than a PKC dependent mechanism is
involved in the modulation of
TNFalpha response by IFbeta-1a on BMECs
Horwood et al., J Exp Med 2003
(Agammaglobulinemia) :
In addition, adenoviral overexpression of
Btk in normal human monocytes
enhanced TNF alpha production ... We examined the
role of
Btk in
TNF alpha production using luciferase reporter adenoviral constructs and have established that overexpression of Btk results in the stabilization of TNF alpha mRNA via the 3 ' untranslated region
Horwood et al., J Immunol 2006
:
Bruton's tyrosine kinase (Btk) , the gene mutated in the human immunodeficiency X-linked agammaglobulinemia, is activated by LPS and is
required for LPS induced
TNF production
Hasan et al., Immunology 2008
:
In this study we set out to investigate the potential
role of
Btk in Toll-like receptor 9 (TLR9) activation and the production of pro-inflammatory cytokines such as interleukin (IL)-6,
tumour necrosis factor (TNF)-alpha and IL-12p40
Schmidt et al., Eur J Immunol 2009
:
Finally, a comparison of WT, Tec ( - ) ( / ) ( - ), Btk ( - ) ( / ) ( - ) and Tec ( - ) ( / ) ( - ) Btk ( - ) ( / ) ( - ) BMMC revealed a negative role for Btk in the regulation of IL-4 production, while for the efficient production of
TNF-alpha , IL-13 and GM-CSF, both Tec and
Btk were
required