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ABCC1 — TNF
Text-mined interactions from Literome
Geier et al., Hepatology 2003
(Cholestasis, Intrahepatic...) :
In endotoxemia, down-regulation of
Mrp2 , and partially in case of Ntcp, could be
prevented by IL-1 beta but not
TNF-alpha blockade
Tanaka et al., Hepatology 2012
(Disease Models, Animal...) :
Furthermore,
tumor necrosis factor-a and transforming growth factor-ß1
induced the expression of Lpcat2/4 and
Abcc1/4 and down-regulated Slc10a1 and Slco1a1 in primary hepatocytes, suggesting an association between the changes in serum LPC and bile acids and proinflammatory cytokines
Cherrington et al., Am J Physiol Gastrointest Liver Physiol 2013
(Enterocolitis, Necrotizing) :
Furthermore, increased levels of
TNF-a and IL-18 in experimental NEC may
play a role in the regulation of Ntcp and
Mrp2 , respectively
Stein et al., J Natl Cancer Inst 1997
(Colonic Neoplasms) :
In this study, we examined the
effects of
tumor necrosis factor-alpha on
MRP and LRP gene expression in the same colon carcinoma cells ... The
effects of
tumor necrosis factor-alpha on
MRP and LRP messenger RNA expression were evaluated by means of reverse transcription and the polymerase chain reaction ; effects on MRP and LRP protein expression were examined by use of specific monoclonal antibodies and flow cytometry ... In transfected cells, the endogenous production of
tumor necrosis factor-alpha reduced LRP gene expression ( both messenger RNA and protein ) and
increased MRP gene expression ( both messenger RNA and protein ), regardless of cell type