Toyoda et al., Gut 2002
(Carcinoma, Hepatocellular...) :
Our study showed that PPARgamma was expressed in human liver cancer cells and that the ligand for PPARgamma, troglitazone, inhibited the growth of these cells by inducing apoptosis through caspase 3 activation, indicating that troglitazone could be potentially useful as an apoptosis inducer for the treatment of HCC
Schultze et al., Apoptosis 2006
(Glioblastoma...) :
This process is accompanied by a substantial increase of active caspase 8 and active caspase 3, but it is independent of troglitazone 's effects on the nuclear receptor PPAR-gamma He et al., Obesity (Silver Spring) 2008
:
The caspase mediated degradation of both PPARgamma1 and PPARgamma2 resulted in the generation of a specific 44-kd cleavage product
Keuper et al., Cell death & disease 2013
:
TRAIL ( TNF related apoptosis inducing ligand ) regulates adipocyte metabolism by caspase mediated cleavage of PPARgamma