◀ Back to IRS1
IRS1 — SH2B2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Insulin Pathway:
Insulin Receptor/Insulin/IRS1 complex (INSR-INS-IRS1)
→
APS homodimer complex (SH2B2)
(modification, activates)
Baumann et al., Nature 2000, Liu et al., Mol Cell Biol 2002, Hu et al., Mol Cell 2003, Ribon et al., Mol Cell Biol 1998
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Duan et al., Mol Cell Biol 2004
(Glucose Intolerance...) :
Moreover,
SH2-B directly
enhanced autophosphorylation of insulin receptor and tyrosine phosphorylation of
IRS1 and IRS2 in an SH2 domain dependent manner in cultured cells
Duan et al., J Biol Chem 2004
:
Consequently,
SH2-B dramatically
enhanced leptin stimulated tyrosine phosphorylation of
IRS1 and IRS2 in HEK293 cells stably expressing LRb, thus promoting association of IRS1 and IRS2 with the p85 regulatory subunit of PI 3-kinase and phosphorylation and activation of Akt ... Similarly,
SH2-B promoted growth hormone stimulated tyrosine phosphorylation of
IRS1 in both HEK293 and MEF cells
Li et al., Endocrinology 2007
:
SH2B2beta markedly
attenuated the ability of SH2B1 to promote JAK2 activation and subsequent tyrosine phosphorylation of
insulin receptor substrate-1 by JAK2