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CRP — IRS1

Text-mined interactions from Literome

Xu et al., Mol Endocrinol 2007 (Insulin Resistance...) : Next, anti-CD64 Fcgamma phagocytic receptor I ( FcgammaRI ), but not anti-CD16 ( FcgammaRIIIa ) or anti-CD32 ( FcgammaRII ) antibody, partially blocked the recombinant CRP induced phosphorylation of JNK and IRS-1 and restored, to a certain extent, the insulin stimulated phosphorylation of Akt ... Piceatannol, an inhibitor of Syk tyrosine kinase, or infection of Syk small interference RNA blocked the recombinant CRP induced RhoA activity and the phosphorylation of JNK and IRS-1 ... We conclude that recombinant CRP induces endothelial insulin resistance and dysfunction, and propose a new mechanism by which recombinant CRP induces the phosphorylation of JNK and IRS-1 at the Ser307 site through a Syk tyrosine kinase and RhoA-activation signaling pathway
D'Alessandris et al., Diabetologia 2007 : C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport