Gene interactions and pathways from curated databases and text-mining

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NOS2 — SPESP1

Text-mined interactions from Literome

Jin et al., Neurosci Res 2009 (Central Nervous System Infections...) : Thus, our results indicate that ESP stimulates microglial expression of iNOS via both PKC dependent and -independent MAPKs phosphorylation and NF-kappaB activation
Wang et al., Int J Parasitol 1997 : In addition, the results of Northern blot analysis showed that ESP suppressed the LPS ( 10 micrograms/ml ) and interferon-gamma ( IFN-gamma, 100 U/ml ) -induced hepatocyte iNOS mRNA expression in a dose dependent fashion and the suppressing effect was more marked when hepatocytes were exposed to ESP 3 h prior to LPS and IFN-gamma